Homocysteine Resist (Vitamin B2, B6, B9, B12): Homocysteine Metabolism, Cardiovascular Health and Neurovascular Protection – Active B Vitamin Complex for Metabolic Balance and Cellular Energy

Homocysteine Resist, Life Extension is an advanced dietary supplement, formulated to support homocysteine metabolism and maintain cardiovascular, neurovascular and metabolic health. The product combines active forms, with high bioavailability, of B complex vitamins, essential in methylation reactions and in the transformation of homocysteine into compounds useful to the body. The formula contains Riboflavin (Vitamin B2) 25 mg, Vitamin B6 in the form of pyridoxal 5'-phosphate (P-5-P) 100 mg, Folate in the form of L-5-methyltetrahydrofolate calcium salt (5-MTHF) 8500 mcg and Vitamin B12 in the form of methylcobalamin 1000 mcg.

Homocysteine is an amino acid naturally produced in the body during methionine metabolism. Under optimal conditions, it is efficiently recycled through two major pathways: remethylation (to methionine) and transsulfuration (to cysteine). When these processes do not function efficiently—due to insufficient B vitamin intake, oxidative stress, unbalanced diet or genetic particularities—homocysteine levels can increase, which is associated with increased oxidative stress and impact on the vascular endothelium (inner layer of blood vessels). For this reason, supporting homocysteine metabolism is considered an important strategy for maintaining vascular health and metabolic balance.

By using active forms of B6 (P-5-P), folate (5-MTHF) and B12 (methylcobalamin), Homocysteine Resist is designed to offer direct support in key biochemical reactions, contributing to optimal function of the cardiovascular system, brain and energy metabolism.

 

Detailed Benefits of Homocysteine Resist (Vitamin B2, B6, B9, B12)

 

• Supporting efficient homocysteine metabolism

Homocysteine metabolism depends on enzymes that need specific cofactors, especially B vitamins. When these cofactors are missing or in forms that are harder to use, homocysteine conversion can become inefficient. Homocysteine Resist provides high doses and bioactive forms for direct support of these metabolic pathways.

Through the intake of active B vitamins, the formula can support:
✅ Supporting homocysteine remethylation – efficient recycling to methionine
✅ Supporting transsulfuration – conversion to useful compounds (precursors for glutathione)
✅ Maintaining amino acid metabolic balance – optimal biochemical function
✅ Support for enzymatic reactions dependent on B6, B9 and B12 – increased efficiency

This support is especially relevant for people pursuing long-term cardiovascular health and overall metabolic balance.

 

• Support for cardiovascular health and endothelial function

The vascular endothelium has a critical role in regulating blood vessel tone, circulation and inflammatory response. Imbalanced homocysteine metabolism is frequently associated with oxidative stress at the vascular level, which can influence vessel elasticity and functionality. B vitamins play an essential role in maintaining a balanced metabolic environment, supporting blood vessel health.

The formula can contribute to:
✅ Supporting endothelial integrity – support for vascular function
✅ Maintaining vessel elasticity – more efficient circulation
✅ Supporting heart health – by optimizing homocysteine metabolism
✅ General metabolic protection – balance between oxidative and regenerative processes

Through these mechanisms, the product becomes a valuable ally for people interested in maintaining cardiovascular health and optimal circulation.

 

• Neurological function and neurovascular protection through efficient methylation

The brain is one of the most metabolically active organs and constantly needs nutrients involved in neurotransmitter synthesis, myelin maintenance and neuronal energy metabolism. Methylation is an essential biochemical process for neurological function, and active folate (5-MTHF) and vitamin B12 (methylcobalamin) are central pieces in this mechanism.

By supporting methylation reactions, the formula can support:
✅ Neurotransmitter synthesis – mental balance and cognitive functions
✅ Maintaining myelin health – support for efficient nerve transmission
✅ Optimal brain function – clarity, focus and mental performance
✅ Supporting neurovascular health – adequate flow and nutrition to brain tissue

This benefit is especially important in periods of stress, mental fatigue or intense intellectual demand.

 

• Cellular energy and efficient nutrient metabolism

B vitamins are directly involved in the transformation of carbohydrates, fats and proteins into energy. Riboflavin (B2) has a central role in redox reactions and in mitochondrial energy production, and B6 contributes to amino acid metabolism and formation of compounds necessary for energy function. When these vitamins are at optimal levels, the body can produce energy more efficiently at the cellular level.

Through concentrated B vitamin intake, the following can be supported:
✅ Energy production at the mitochondrial level – vitality and resistance
✅ Macronutrient metabolism – efficient food utilization
✅ Reduction of fatigue associated with B vitamin deficiency – support for tone
✅ Balanced metabolic function – supporting daily energy processes

This aspect makes the supplement relevant also for people who want support in periods of intense activity or accumulated fatigue.

 

• Active forms and high bioavailability for superior efficiency

A major advantage of this product is the use of active forms, directly usable by the body:

• Vitamin B6 is in the form of pyridoxal 5'-phosphate (P-5-P), the active coenzyme form.

• Folate is in the form of L-5-methyltetrahydrofolate (5-MTHF), the biologically active form involved in methylation.

• Vitamin B12 is in the form of methylcobalamin, the active form used directly in metabolic reactions.

These forms can offer:
✅ Rapid metabolic utilization – without complex conversions
✅ Superior efficiency in methylation reactions – direct support for biochemical cycles
✅ Increased absorption and activity – compared to conventional forms
✅ Support adapted to modern needs – demanding lifestyle and high metabolic requirements

 

• Supporting glutathione synthesis and antioxidant protection

Homocysteine metabolism is linked to the availability of precursors for glutathione, one of the body's most important endogenous antioxidants. By supporting the transsulfuration pathway (dependent on B6), the body can favor the production of compounds involved in cellular detoxification and protection against oxidative stress.

This support can contribute to:
✅ Internal antioxidant protection – balance against free radicals
✅ Supporting cellular detoxification – through the body's natural mechanisms
✅ Maintaining cellular health – reducing oxidative stress
✅ Support for metabolic resilience – better adaptation to environmental factors

 

 

Adjuvant in Various Conditions:

• In collaboration with antioxidants, such asvitamin C andvitamin E, it can contribute to protecting cells against oxidative damage. Also, association withomega-3 fatty acids can support heart, brain and vascular system health, while essential minerals, such asmagnesium, can help relax blood vessels and maintain a healthy heart rhythm.

 

Directions for Use

Read the entire label and follow directions carefully before use.
Take one (1) capsule daily, with food, or as recommended by a healthcare practitioner.




 

Supplement Facts
Serving Size: 1 Vegetarian Capsule
	Amount Per Serving	%Daily Value
Riboflavin (vitamin B2)	25 mg	1923%
Vitamin B6 (as pyridoxal 5'-phosphate)	100 mg	5882%
Folate (as L-5-methyltetrahydrofolate calcium salt)	8500 mcg°	2125%
Vitamin B12 (as methylcobalamin)	1000 mcg	41667%
**Daily Value not established. °DFE (Dietary Folate Equivalents).

 

Other Ingredients

Microcrystalline cellulose, vegetable cellulose (capsule), stearic acid, silica, rice extract blend.

 

Warnings

Do not use this product if you are being treated with methotrexate, fluorouracil, phenytoin, phenobarbital, primidone or levodopa before consulting with your healthcare provider.
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or nursing. Store tightly closed in a cool, dry place.