L-Histidine 500 mg (AjiPure®): Tissue Regeneration, Immune Support and Antioxidant Protection – Essential Amino Acid for Metabolism, Energy and Inflammatory Balance

L-Histidine, 500 mg, AjiPure®, Swanson is a premium dietary supplement that provides 500 mg pharmaceutical-grade L-histidine, obtained under the AjiPure® standard – a recognized benchmark for purity, consistency and bioavailability. L-histidine is an essential amino acid (especially relevant during periods of growth, metabolic stress or increased physiological requirements), with key roles in protein synthesis, immune function, tissue maintenance and acid-base balance regulation. In addition, histidine is a precursor for histamine and participates in the formation of carnosine, an important dipeptide for antioxidant protection, muscle function and "buffering" of acidity at the cellular level.

In the body, amino acids are not just "building blocks" for proteins, but functional molecules that influence metabolism, recovery, cellular signaling and stress adaptation. L-histidine stands out for its involvement in tissue regeneration processes, protection against oxidative stress and immune function support, being of interest to active people, those in periods of physical or mental stress and anyone pursuing nutritional support oriented towards performance and internal balance.

Detailed Benefits of L-Histidine 500 mg (AjiPure®)

• Supporting protein synthesis and tissue regeneration

Protein synthesis is a fundamental process for maintaining muscle mass, tissue repair and recovery after effort. L-histidine directly participates in the construction of structural and enzymatic proteins, contributing to maintaining tissue integrity and the body's adaptation to stress.

L-histidine can contribute to:
• Supporting muscle recovery after physical activity
• Maintaining connective and structural tissues through efficient protein synthesis
• Better recovery during periods of increased physiological stress

Benefits may include:
✅ Faster recovery after effort or demanding periods
✅ Supporting muscle tone and physical resistance
✅ Support for tissue regeneration in the context of an active lifestyle

Through this role, histidine becomes an amino acid of interest for performance, recovery and maintaining body structure.

• Carnosine formation – antioxidant protection and support for muscle performance

One of the most important roles of histidine is its participation in carnosine synthesis (together with beta-alanine). Carnosine is concentrated especially in muscles and brain, where it acts as an antioxidant and as a "buffer" for acidity produced during intense effort. The accumulation of hydrogen ions in muscles contributes to the burning sensation and performance decline; carnosine helps maintain a more stable cellular environment.

L-histidine can support:
• Supporting antioxidant capacity through carnosine formation
• Maintaining performance in anaerobic or demanding efforts
• Protecting cells against oxidative stress and glycation

Benefits may include:
✅ Improved muscle endurance and better effort tolerance
✅ Cellular protection against free radicals generated by stress and training
✅ Support for maintaining tissue quality long-term

This mechanism is relevant both for athletes and for people who want antioxidant support oriented towards muscle tissue.

• Supporting immune function and balanced inflammatory response

The immune system relies on rapid protein synthesis (antibodies, receptors, cytokines) and on the balance between defense reactions and inflammation control. Histidine is used in protein synthesis processes involved in immune cell function and can support an efficient immune response, especially during periods of stress, fatigue or recovery.

L-histidine can contribute to:
• Supporting the production of proteins involved in immune defense
• Maintaining inflammatory balance through complex metabolic roles
• Supporting the body during periods of stress or seasonal vulnerability

Benefits may include:
✅ Better resilience against external factors
✅ Supporting recovery after periods of overexertion
✅ More balanced immune system function

This support is valuable for active people, those with busy schedules and anyone pursuing general health maintenance.

• Role in histamine formation and supporting cellular communication

Histidine is a precursor for histamine, a molecule with an important role in signaling, immune responses and regulation of digestive secretions. Histamine is involved in normal physiological processes, including communication between immune cells and the body's adaptation to external stimuli. Through histidine intake, the body can maintain the availability of the substrate needed for these signaling processes, within the limits of individual needs.

Histidine can support:
• Physiological cellular signaling processes
• The body's adaptive response to external stimuli
• Digestive function through indirect roles in secretions and regulation

Benefits may include:
✅ Supporting integrated body function
✅ Better adaptation to stress and demands
✅ Functional balance through supporting biochemical communication

This role highlights that histidine acts beyond simple protein synthesis, also impacting fine regulatory mechanisms.

• Supporting energy metabolism and enzymatic functions

Enzymes are specialized proteins that control metabolic reactions, including those related to energy production, detoxification and nutrient utilization. As an amino acid involved in the structure of many proteins and enzymes, histidine contributes to optimal metabolism function, including processes that occur in mitochondria and in tissues with high energy requirements.

L-histidine can contribute to:
• Supporting energy metabolism through its role in enzyme synthesis
• Maintaining cellular functions during periods of metabolic stress
• Supporting general vitality through efficient nutrient utilization

Benefits may include:
✅ More stable energy and resistance to fatigue
✅ Supporting mental clarity through metabolic support
✅ Better adaptation to effort and more efficient recovery

This benefit is relevant for people who want performance and vitality, both physically and mentally.

• Cellular protection against oxidative stress and glycation processes

Oxidative stress and glycation (binding of sugars to proteins, altering their function) are processes associated with biological aging and structural tissue deterioration. Through histidine's role in carnosine formation and its ability to interact with free radicals and glycation products, better protection of structural and enzymatic proteins is supported.

Histidine can help with:
• Supporting endogenous antioxidant mechanisms
• Protecting proteins against oxidative degradation
• Maintaining tissue quality long-term

Benefits may include:
✅ Better cellular resilience and metabolic protection
✅ Supporting muscle health and connective tissues
✅ Support for functional longevity and vitality

L-Histidine 500 mg (AjiPure®), Swanson offers a high-purity amino acid supply, with essential roles in protein synthesis, tissue regeneration, antioxidant protection, energy metabolism and immune support. Through its multidirectional action, histidine becomes a valuable nutrient for performance, recovery and maintaining physiological balance in everyday life.

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