PEA400, Palmitoylethanolamide: Natural Support for Inflammation, Neuropathic Pain and Immune Balance – Advanced Supplement for Nervous System and Tissue Health

PEA400, 400 mg, Natural Factors is a high-quality dietary supplement that contains Palmitoylethanolamide (PEA), a natural compound present in the body and in certain foods, with an essential role in inflammation regulation, chronic pain control and supporting nervous system balance. Palmitoylethanolamide is an endogenous fatty acid amide, biosynthesized naturally in response to inflammation, cellular stress or trauma. Its anti-inflammatory and neuroprotective action has been highlighted in numerous clinical studies, being used extensively for alleviating neuropathic pain, fibromyalgia, chronic inflammation and immune disorders.
 

Being formulated from safflower oil – a natural source of essential fatty acids – the PEA400 product offers high bioavailability and efficient absorption. PEA supplementation is a safe and effective therapeutic option for people suffering from inflammatory conditions, chronic pain, nerve sensitivity or immune system dysfunctions.


 

Detailed Benefits of Palmitoylethanolamide (PEA)

• Reducing chronic and acute inflammation

Inflammation is a natural defense process of the body, but when it becomes chronic, it can lead to tissue deterioration, persistent pain and the onset of degenerative diseases. PEA acts as a pro-homeostatic mediator that regulates the release of pro-inflammatory cytokines, balancing the immune response without suppressing the body's natural defense.

Mechanisms by which PEA reduces inflammation include:
✅ Inhibiting mast cell activation – cells involved in inflammatory and allergic response
✅ Decreasing production of inflammatory cytokines (TNF-α, IL-1β, IL-6)
✅ Modulating PPAR-α receptors – which regulate inflammation and lipid metabolism

Through its targeted action, PEA contributes to:
• Reducing pain and joint stiffness
• Improving inflammatory symptoms in arthritis, tendinitis and other rheumatic conditions
• Enhancing mobility and quality of life in chronic inflammatory diseases

• Ameliorating neuropathic and chronic pain

Neuropathic pain is often difficult to treat and occurs due to peripheral nerve or central nervous system damage. This is encountered in conditions such as sciatica, carpal tunnel syndrome, fibromyalgia, multiple sclerosis or post-surgical pain. PEA is recognized as a natural analgesic that acts on the cause of pain – neurogenic inflammation – without creating dependence or significant side effects.

PEA intervenes through:
✅ Regulating microglial activity – immune cells in the central nervous system involved in chronic pain
✅ Reducing nerve hypersensitivity by stabilizing neuronal membranes
✅ Inhibiting nociceptive signals through indirect action on cannabinoid receptors (CB1, CB2)

Through these mechanisms, PEA effectively contributes to:
• Soothing chronic pain without psychoactive effects
• Reducing nerve hypersensitivity in affected areas
• Improving sleep quality and emotional state in patients with persistent pain

• Supporting immune system balance

PEA is a natural modulator of the immune system, acting without compromising the body's defense function. In the context of autoimmune diseases, allergies or recurrent inflammation, PEA contributes to reducing excessive immune reactions and associated oxidative stress.

Mechanisms by which PEA regulates the immune system:
✅ Inhibits excessive activation of immune cells (mast cells, macrophages)
✅ Reduces release of inflammatory mediators during allergic reactions
✅ Contributes to balancing the neuro-immuno-endocrine axis

These properties recommend PEA in supporting people with:
• Chronic allergies, rhinitis, asthma with inflammatory component
• Mild autoimmune diseases, where inflammation regulation is essential
• Supporting a balanced immune response during periods of stress or convalescence

• Neuroprotection and cognitive function support

Palmitoylethanolamide has an essential role in maintaining neuronal health, protecting nerve cells from oxidative stress, inflammation and excitotoxicity. Preclinical and clinical studies indicate that PEA can support memory, concentration and mental clarity, especially in conditions of neuroinflammatory stress or aging.

PEA's neuroprotective actions include:
✅ Stabilizing neuronal homeostasis in the face of oxidative stress and inflammation
✅ Reducing microglial activation – responsible for neuronal deterioration in neurodegenerative diseases
✅ Potentiating endocannabinoid action – involved in neuroplasticity and emotional balance

Thus, PEA can support:
• Cognitive function during mentally demanding periods
• Neurological recovery after trauma or surgical interventions
• Reducing risk of neurodegenerative conditions through neuron protection

• Supporting muscle and tissue health

Localized inflammation in muscle and connective tissues is a frequent factor in muscle pain, tendinitis and chronic overuse. PEA reduces muscle discomfort through mechanisms similar to those observed in the nervous system – reducing inflammation, improving local circulation and calming the nociceptive response.

Its beneficial effects on tissue health include:
✅ Reducing edema and inflammation in traumatized areas
✅ Alleviating muscle pain and post-exercise stiffness
✅ Faster recovery after physical exertion or minor injuries

These benefits make PEA ideal for:
• Active people or athletes experiencing recurrent muscle pain
• Recovery after sprains, dislocations or connective tissue inflammation
• Maintaining mobility and comfort in daily life

• Excellent tolerance and increased bioavailability

A significant advantage of PEA is its favorable safety profile. Being an endogenous compound (also produced by the human body), PEA is well tolerated even in long-term use. It does not produce sedation, does not interfere with cognitive functions and does not induce dependence. The form used in the PEA400 product, derived from safflower oil, ensures efficient absorption and long-term stability.

Thus, PEA can be used:
• As complementary therapy in chronic pain, without the risks associated with classic analgesics
• In supporting immune and neuroinflammatory balance at any age
• As part of a holistic protocol for inflammation and pain management


Through its complex actions, PEA supports cellular health, nervous and immune system function, actively contributing to maintaining optimal physiological balance. Whether used for pain control, inflammation reduction or cognitive function support, PEA400 is a valuable ally for anyone seeking natural, effective and safe solutions.

Suggested Use

1 capsule 1-3 times daily or as directed by a health care practitioner.

Other ingredients

Microcrystalline cellulose, vegetarian capsule (carbohydrate gum [cellulose], purified water), magnesium stearate (vegetable grade), stearic acid, silica.

Contains no artificial colors, preservatives or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts or GMOs.

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Warnings

As with any supplement, consult your doctor before use if you are pregnant, nursing or trying to conceive, or if you are taking medications, have a medical condition or anticipate a surgery. Keep out of reach of children.

Sealed for your protection. Do not use if seal is broken. For freshness, keep in a cool, dry place.