Folate (5-Methyltetrahydrofolic Acid) 680 mcg DFE – Efficient methylation, cellular energy, homocysteine balance and cognitive function support with Quatrefolic®

Active folate 5-MTHF represents the biologically functional form of folate, directly involved in methylation, DNA/RNA synthesis, neurotransmitter production and red blood cell formation. Unlike synthetic folic acid, 5-methyltetrahydrofolate (5-MTHF) bypasses the MTHFR-dependent conversion steps and is rapidly available for key metabolic pathways. The Swanson formula uses Quatrefolic® – [6S]-5-MTHF glucosamine salt – a next-generation technology with superior stability and solubility. Each capsule provides 680 mcg DFE (Dietary Folate Equivalents), equivalent to 740 mcg 5-MTHF (glucosamine salt), supporting a broad spectrum of cellular processes: homocysteine balance, mitochondrial energy, mental clarity and resilience to daily stress.

Detailed benefits of Folate (5-MTHF) with Quatrefolic®

• Active methylation and homocysteine balance

Methylation is the biochemical "switch" that influences essential syntheses – from DNA and neurotransmitters to phospholipids.

5-MTHF is the functional methyl donor from the folate cycle:
✅ Supports conversion of homocysteine to methionine, contributing to a balanced metabolic profile.
✅ Supports synthesis of S-adenosylmethionine (SAMe), the universal "currency" of methylation.
✅ Favors epigenetic processes and fine adjustments of genetic expression at cellular level.

Efficient methylation is reflected in stable energy, mental clarity and well-coordinated regeneration processes.

• Cellular energy and DNA/RNA synthesis

Active folate participates in manufacturing DNA/RNA "building blocks" (purines/pyrimidines) and in one-carbon unit transfer:

✅ Contributes to cell multiplication and differentiation, with impact on tissues with rapid turnover.
✅ Supports genetic material integrity in maintenance and repair processes.
✅ Helps, together with B complex, achieve biochemical efficiency of energy chains.

When nucleic acid synthesis is properly supported, tissues regenerate more coherently, and the body better tolerates intense periods.

• Mental clarity, mood and neurotransmitters

5-MTHF is involved in the synthesis of key neurotransmitters (dopamine, serotonin, norepinephrine) through co-participation in methylation reactions:

✅ Favors balanced mood and a state of "alert calm."
✅ Contributes to focus and cognitive fluency in periods of intellectual work.
✅ Helps maintain stable mental rhythm throughout the day.

Neurotransmitter balance translates into concentration, motivation and productivity.

• Genetic compatibility (MTHFR) and bioavailability

Some people have MTHFR gene variants that limit the conversion of folic acid to 5-MTHF.

Choosing the active form:
✅ Bypasses the limiting enzymatic step, ensuring immediate folate availability.
✅ Reduces individual variability of response compared to non-activated forms.
✅ Offers more predictable support for cognitive and energy objectives.

This functional compatibility makes 5-MTHF a modern option for daily support.

• Cardiovascular health – through the homocysteine-methionine axis

Homocysteine balance is correlated with folate, B12 and B6 status:
✅ 5-MTHF supports homocysteine conversion, supporting endothelial homeostasis.
✅ In synergy with B12 (methylcobalamin) and B6, contributes to functional vascular response.
✅ Helps maintain pleasant perception of energy in daily activities.

A well-supported methylation axis means better orchestrated circulatory processes.

• Hematopoietic function and efficient oxygenation

Active folate supports normal red blood cell formation:

✅ Contributes to synthesis of components necessary for erythropoiesis.
✅ Supports efficient oxygen transport to tissues.
✅ Helps achieve perception of functional resistance in daily life.

Harmonized hematopoiesis is reflected in tone and mental clarity.

• Skin, hair and tissues – structural regeneration

Cell replication processes influence epidermis, appendages and mucous membranes:
✅ 5-MTHF supports DNA/RNA synthesis necessary for cell renewal.
✅ Contributes, in synergy with antioxidants and quality proteins, to maintaining well-groomed skin appearance.
✅ Helps achieve comfort of tissues exposed daily to environmental stressors.

Coherent regeneration supports visible tissue resilience.

• "Clean energy" and better tolerance to mental tasks

Efficient methylation and sustained syntheses translate into stable energy state:
✅ 5-MTHF contributes to fluid metabolic rhythm between meals.
✅ Favors availability for intellectual effort and quick decisions.
✅ Helps achieve smoother transition between tasks, with fewer mental "blocks."

Energy stability means more consistency in results.

• Quatrefolic® – quality standard for 5-MTHF

Quatrefolic® is a patented form of [6S]-5-MTHF glucosamine salt, recognized for:

✅ High solubility and superior stability compared to other salts.
✅ Consistent bioavailability and predictable cellular utilization profile.
✅ Traceability and batch-to-batch consistency, essential for medium-term objectives.

This technology ensures that the active form reaches where it's needed, when it's needed.

• Recommended nutritional synergies

5-MTHF works excellently together with:
— Vitamin B12 (methylcobalamin) and B6 (pyridoxal-5-phosphate) for complete methylation.
— Choline, betaine (TMG) and inositol for membrane phospholipids and lipotropic flow.
— Magnesium for enzymatic cofactors involved in over 300 metabolic reactions.
— Omega-3 (EPA/DHA) for membrane fluidity and neuronal comfort.
— Iron (if necessary from diet) for heme synthesis, in personalized programs.

These combinations amplify effects on energy, clarity and resilience.

• Natural integration into lifestyle

5-MTHF efficiency is seen when supported by coherent habits:
✅ Diet rich in leafy greens, legumes, nuts and seeds.
✅ Adequate hydration and regular sleep schedule for memory consolidation.
✅ Moderate movement for tissue perfusion and cognitive "restart."

Daily coherence transforms biochemical support into visible performance.

• Why choose Folate (5-MTHF) 680 mcg DFE, Swanson – Quatrefolic®

• Efficient methylation and homocysteine balance for coherent metabolism.
- Cellular energy, DNA/RNA synthesis and well-coordinated regeneration processes.
- Mental clarity, balanced mood and sustained focus.
- Compatibility with MTHFR variations – active form, immediately available.

- Hematopoietic support and efficient tissue oxygenation.
- Structural regeneration for skin, hair and mucous membranes.
- Simple synergies with B12/B6, choline-betaine, magnesium and omega-3.
- Quatrefolic® – [6S]-5-MTHF with superior stability, solubility and traceability; Swanson quality, clear dosage: 680 mcg DFE – 170%.

Folate (5-MTHF) 680 mcg DFE, Swanson, elegantly completes the central link of methylation and cellular syntheses, offering a modern foundation for stable energy, cognitive clarity and metabolic balance – in an active, predictable formula that is easy to integrate into daily routine.




 

Directions for use

As a dietary supplement, take one vegetarian capsule daily with water.




 

Other ingredients

Brown rice flour, hypromellose (vegetable capsule), magnesium stearate. 

Warnings

For adults only. Consult your healthcare provider before using this product or any other product if you are pregnant or nursing, taking medication or have a medical condition.
Keep out of reach of children. Do not use if seal is broken. Store in a cool, dry place.