Spermidine: Autophagy, Cellular Longevity and Cardiovascular Health – Premium Supplement For Regeneration and Rejuvenation

Spermidine 10 mg, Double Wood Supplements contains spermidine trihydrochloride (Spermidine 3HCl), a natural compound present in the body's cells, known for its essential role in supporting autophagy – the process by which cells clean and recycle damaged components. By stimulating autophagy, spermidine contributes to maintaining cellular health, supports longevity and helps prevent the accumulation of toxic materials in cells.

As we age, the level of endogenous spermidine decreases, which leads to a reduction in autophagy efficiency and an accumulation of damaged and dysfunctional proteins in the body. This decrease can accelerate the aging process and can promote the onset of degenerative diseases. Supplementation with spermidine helps restore this cellular balance, having beneficial effects on longevity, cognitive health, cardiovascular function and cellular regeneration.

Detailed Benefits of Spermidine

• Stimulating autophagy – the natural process of cellular cleaning

Autophagy is the mechanism by which cells eliminate worn, damaged or toxic components, thus maintaining a healthy intracellular environment. This process is crucial for preventing cellular dysfunctions, for regenerating organelles (including mitochondria) and for protection against oxidative stress.

As we age, autophagy slows down, which leads to:

• Accumulation of damaged proteins and organelles

• Mitochondrial dysfunctions

• Increased oxidative stress and inflammation

Spermidine activates autophagy by inhibiting acetyltransferases, enzymes that suppress this process. Thus:
✅ Recycling of damaged cellular components is stimulated
✅ Mitochondrial health and efficiency is maintained
✅ The risk of toxic protein accumulation, associated with neurodegenerative diseases, is reduced

Through these effects, spermidine supports continuous cell regeneration, keeping them functional and healthy in the long term.

• Support for cardiovascular health

Spermidine has an essential role in maintaining heart and blood vessel health. By stimulating autophagy and reducing oxidative stress, spermidine contributes to:

• Protecting the vascular endothelium – the inner layer of blood vessels

• Reducing systemic inflammation, a key factor in cardiovascular diseases

• Improving arterial elasticity and blood flow

Several epidemiological studies have shown that increased spermidine intake is associated with:
✅ Reduced risk of arterial hypertension
✅ Improved cardiac function
✅ Decreased cardiovascular mortality

Through these mechanisms, spermidine can contribute to maintaining cardiovascular health, supporting optimal functioning of the heart and circulatory system.

• Improving cognitive health and preventing neuronal decline

Autophagy has an essential role in brain health, as it helps eliminate defective proteins and protein aggregates, which can contribute to the development of neurodegenerative diseases, such as Alzheimer's or Parkinson's. Spermidine supports neuronal health by:

• Reducing the accumulation of beta-amyloid and tau, proteins associated with Alzheimer's

• Protecting neurons against oxidative stress and inflammation

• Stimulating synaptic regeneration and neuronal plasticity

The benefits of spermidine for cognitive health include:
✅ Improving memory and concentration
✅ Slowing age-related cognitive decline
✅ Protection against neurodegenerative conditions

Thus, spermidine not only supports daily cognitive function, but actively contributes to protecting the brain in the long term.

• Supporting longevity and cellular health

Spermidine is recognized for its effects on longevity, demonstrated in numerous studies on animal and human models. This effect is due to:

• Activation of autophagy, which cleans and regenerates cells

• Reduction of chronic inflammation, a major factor in accelerated aging

• Protection against oxidative stress, which damages DNA and mitochondria

• Improvement of cellular metabolism

Through these mechanisms, spermidine can:
✅ Extend cell lifespan
✅ Prevent premature aging of tissues
✅ Maintain optimal organ functioning in the long term

• Optimizing metabolic health

A healthy metabolism is essential for maintaining body weight, regulating blood sugar levels and preventing metabolic diseases. Spermidine contributes to metabolic health by:

• Reducing inflammation that contributes to insulin resistance

• Improving insulin sensitivity

• Supporting fat oxidation and energy metabolism

Thus:
✅ The risk of type 2 diabetes is reduced
✅ Glycemic control is improved
✅ A healthy metabolic balance is maintained

• Protection against oxidative stress and supporting antioxidant processes

Oxidative stress, caused by the imbalance between free radicals and antioxidants, is a major factor in cellular aging and the onset of chronic diseases. Spermidine has indirect antioxidant properties, through:

• Stimulating autophagy, which eliminates damaged cellular components

• Reducing chronic inflammation

• Improving mitochondrial function, which reduces free radical production

This contributes to:
✅ Maintaining cellular integrity
✅ Preventing DNA and protein damage
✅ Supporting the general health of the body

• Strengthening the immune system and preventing chronic inflammation

A balanced immune system is essential for preventing infections and chronic diseases. Spermidine contributes to regulating the immune response by:

• Reducing low-grade systemic inflammation

• Supporting the regeneration of immune cells through autophagy

• Improving the balance between inflammatory and anti-inflammatory processes

Benefits for immunity include:
✅ More efficient immune response
✅ Prevention of chronic inflammatory diseases
✅ General protection against external stressors


 

Suggested use:

Take 1 serving per day. After 1 week of use you can increase the dose to 2 servings per day. Take with or without food.



 

Other ingredients:

HPMC capsule, rice flour.

 

Warning:

Consult your physician before use. Do not use Spermidine if you are pregnant, nursing or under 18 years of age.
Discontinue use and consult your physician immediately if adverse reactions occur. Do not use Spermidine and do not operate heavy machinery until you know how it affects you. Keep out of reach of children. Do not exceed 4 capsules per day.