Methyl B-12 (Methylcobalamin) + Folate (Quatrefolic®), 5,000 mcg – Neuronal energy, mental clarity, balanced homocysteine and daily vitality – Methylated complex for maximum absorption and efficiency

Methyl B-12 Methylcobalamin plus Folate, 5,000 mcg, NOW Foods is a premium supplement designed to rapidly deliver the bioactive forms of the most important B vitamins involved in methylation, neuronal energy and homocysteine balance. Each serving provides Vitamin B-12 (methylcobalamin) – 5 mg (5,000 mcg) – 208,333% NRV and Folate – 680 mcg DFE [400 mcg (6S)-5-MTHF from Quatrefolic® – 170% NRV]. Methylcobalamin is the coenzyme form of vitamin B-12, ready for cellular use, and Quatrefolic® (5-MTHF) represents methylated folate, directly active, independent of MTHFR conversion. Together, these forms support methylation, synapse and neurotransmission, energy production (ATP) and DNA synthesis, being suitable for periods of intellectual demand, lifestyle transitions, intense schedules or daily vitality goals.

Detailed Benefits of Methyl B-12 + Folate (Quatrefolic®)

• Neuronal energy and mental clarity

The nervous system needs methylated cofactors to support work pace and cognitive flow. When B-12/folate status is suboptimal, the following may occur:
• mental “fog” and inconsistent focus;
• fatigue with repetitive tasks;
• diminished processing speed.

Through the synergy of methylcobalamin and 5-MTHF:
✅ energy production pathways at the neuronal level are supported;
✅ coherence in multitasking increases;
✅ mental clarity is maintained throughout the day.

• Efficient methylation and homocysteine balance

Methylation is a key process for detoxification, epigenetics and neurotransmitter synthesis. In the absence of active forms:
• homocysteine may remain at suboptimal levels;
• methionine and SAMe synthesis is inefficient;
• cellular repair processes slow down.

With 5-MTHF (Quatrefolic®) and methylcobalamin:
✅ the conversion of homocysteine to methionine is supported;
✅ methylation cycles are fueled;
✅ a clean and predictable metabolic framework is created.

• Supporting mood and “active calm”

Neurotransmitters (serotonin, dopamine, GABA) depend on B cofactors for synthesis and balance. Without this background:
• mood becomes variable;
• stress is perceived more intensely;
• motivation decreases.

Methyl B-12 + Folate:
✅ provides direct cofactors for synthesis pathways;
✅ supports emotional stability and resilience;
✅ favors lucid calm, without lethargy.

• DNA/RNA synthesis and cellular regeneration

Tissues with rapid turnover require active folate for division and repair. When intake is insufficient:
• regeneration quality decreases;
• fatigue accumulates;
• stress adaptation efficiency decreases.

5-MTHF:
✅ participates in nucleic base synthesis;
✅ supports replication integrity;
✅ contributes to “clean” tissue restoration.

• Energy metabolism and daily vitality

Efficient metabolism converts nutrients into stable energy. In subtle deficits:
• afternoon “crashes” appear;
• support for daily effort is fragile;
• recovery is slow.

Methylcobalamin:
✅ contributes to the conversion of carbohydrates and fats into ATP;
✅ supports oxygen utilization in mitochondria;
✅ provides “clean” energy, without agitation.

• Cognitive comfort during periods of accelerated learning

Learning, memorization and creativity require well-supported neuronal pathways. In the absence of cofactors:
• memory consolidation is inconsistent;
• focus fragments;
• ideas flow with difficulty.

With Methyl B-12 + 5-MTHF:
✅ synaptic plasticity is supported;
✅ attention “bandwidth” increases;
✅ ideas organize more fluidly.

• Compatibility with genetic diversity (MTHFR)

Some people convert folic acid to 5-MTHF with more difficulty. This can mean:
• unpredictable methylation;
• neurotransmitter imbalances;
• “slow” responses to supplements.

Quatrefolic® (5-MTHF):
✅ bypasses conversion step;
✅ is bioavailable regardless of MTHFR status;
✅ ensures consistency of effects.

• Support for hair, skin and nails – from within

Tissue quality depends on protein synthesis, cell division and methylation. When these are “in deficit”:
• skin loses its luminosity;
• hair becomes fragile;
• nails exfoliate.

B-12 + active folate:
✅ support normal synthesis of structural proteins;
✅ support healthy cell turnover;
✅ contribute to a well-groomed appearance, from within.

• Supporting cognitive function at active ages

As the volume of information increases, so do the requirements for nervous cofactors. Without support:
• adaptation to new tasks is delayed;
• recall capacity fluctuates;
• mental fatigue sets in.

Methylcobalamin:
✅ supports nervous function;
✅ contributes to clarity and recall;
✅ maintains decision “finesse”.

• Lifestyle synergies

Effects are amplified alongside:
• sleep hygiene and proper light exposure;
• quality protein intake and omega-3;
• moderate movement and constant hydration.

Thus, Methyl B-12 + Folate:
✅ closes the circle between nutrition and mental performance;
✅ stabilizes daytime energy;
✅ supports long-term well-being.

• Why this formula

Methyl B-12 Methylcobalamin plus Folate, 5,000 mcg, NOW Foods combines two bioactive forms – methylcobalamin and 5-MTHF (Quatrefolic®) – for a rapid and predictable impact on methylation, neuronal energy and cognitive clarity. The high dose of B-12 (5,000 mcg) supports “clean” energization, while methylated folate provides a bypass for folic acid conversion limitations, with immediate availability. The structure of this formula is oriented towards those who desire stable focus, balanced mood, daily vitality and a clean metabolic background, regardless of life's pace or MTHFR genetic variability.

In the context of a balanced routine – sleep, nutrition, movement and stress management – Methyl B-12 + Folate (Quatrefolic®) becomes a central piece for sustainable mental performance: attention that “holds”, coherent memory, linear energy and a state of well-being that shows in the way you work, learn and recover, day by day.




 

Usage Instructions

Take 1 lozenge daily with a meal. Chew the lozenge or hold it in your mouth until it dissolves and swallow.




 

Other Ingredients

Fructose, sorbitol, hydroxypropyl cellulose, microcrystalline cellulose, citric acid, stearic acid (vegetable source), natural flavors and magnesium stearate (vegetable source).
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish ingredients or tree nuts. Produced in a GMP facility that processes other ingredients containing these allergens.

Warnings

For adults only. Consult physician if pregnant/nursing, taking medication or have a medical condition. Keep out of reach of children.