BioActive Folate & Vitamin B12: Neural Energy, Optimized Methylation and Nervous System Health – Advanced Support For Homocysteine, Cognition and Blood Formation

BioActive Folate & Vitamin B12, Life Extension is a supplement formulated to deeply support methylation metabolism, nervous system health, normal red blood cell formation and homocysteine balance. The product combines two essential bioactive forms: folate in the form of L-5-methyltetrahydrofolate (L-5-MTHF), 680 mcg DFE (dietary folate equivalents), i.e. 170% NRV, and vitamin B12 in the form of methylcobalamin, 300 mcg – a high dose, easily usable by the body, which provides 12,500% of the daily reference value.

Unlike synthetic forms of folic acid and cyanocobalamin, L-5-MTHF and methylcobalamin are directly active forms, which the body no longer needs to convert. This is particularly important for people with genetic variations at MTHFR enzyme level or other enzymes involved in methylation, who may have difficulties in proper utilization of ordinary folic acid. By providing active forms, BioActive Folate & Vitamin B12 ensures efficient support for DNA synthesis, cellular regeneration, normal nervous system function, psychological balance and homocysteine metabolism.

Methylation is a fundamental biochemical process, involved in detoxification, neurotransmitter synthesis (serotonin, dopamine, noradrenaline), hormonal balance, genetic expression and energy production. An optimal intake of active folate and vitamin B12 contributes to maintaining these processes at an optimal level, supporting both mental energy and body resilience against physical and emotional stress.

Detailed Benefits of BioActive Folate & Vitamin B12, Life Extension

• Supporting Energy Levels and Reducing Fatigue

Folate and vitamin B12 play a key role in energy metabolism, especially through participation in DNA, RNA synthesis and red blood cell formation, which transport oxygen throughout the body.

When these vitamins are deficient, the following may appear:
• Persistent fatigue and lack of energy
• Decreased effort resistance
• Generalized weakness sensation

Through L-5-MTHF and methylcobalamin intake:
✅ Normal red blood cell production is supported, favoring tissue oxygenation
✅ It contributes to normal energy metabolism, reducing fatigue sensation
✅ A state of vitality and tone in daily life is supported

This combination is useful both for people with demanding lifestyle and high stress, and for those who want to optimize their mental and physical energy level.

• Supporting Nervous System and Cognitive Functions

Vitamin B12 and active folate are essential for myelin sheath integrity that surrounds nerve fibers, for neurotransmitter synthesis and for normal nerve impulse transmission.

Imbalances at this level can manifest through:
• Concentration and memory disorders
• Irritability, anxiety or unstable mood
• Numbness or tingling sensations in extremities

BioActive Folate & Vitamin B12 can contribute to:
✅ Supporting mental clarity and memory
✅ Maintaining normal nervous system function
✅ Supporting emotional balance, through involvement in neurotransmitter synthesis

Methylcobalamin is the form of B12 used directly in the nervous system, which makes it ideal for supporting cognitive and neurological function, while L-5-MTHF participates in the methylation cycle, indirectly influencing cerebral chemical mediator synthesis.

• Balancing Homocysteine and Supporting Cardiovascular Health

Homocysteine is an intermediate amino acid of methionine metabolism. When homocysteine levels rise above optimal range, blood vessel and heart health can be affected. Active folate and vitamin B12 participate together in transforming homocysteine into methionine, reducing its accumulation in blood.

Through supplementation with BioActive Folate & Vitamin B12:
✅ Normal homocysteine metabolism is supported
✅ Proper vascular endothelium function is supported
✅ It contributes to protecting the cardiovascular system, in the context of a healthy lifestyle

This action is particularly important for people who have diet poor in green leafy vegetables or animal foods, or for those with cardiovascular risk factors and increased oxidative stress.

• Support for DNA Synthesis, Cell Division and Regeneration

L-5-MTHF and vitamin B12 are directly involved in nucleotide synthesis necessary for DNA and RNA formation, making them indispensable in cell division and tissue regeneration.

When intake is insufficient, the normal rhythm of cellular renewal can be disrupted, having impact on:
• Bone marrow (blood formation)
• Mucous membranes (digestive, oral)
• Skin and hair

BioActive Folate & Vitamin B12:
✅ Supports cell multiplication and differentiation processes
✅ Contributes to maintaining health of tissues with rapid regeneration
✅ Is important during growth, recovery or increased biological stress periods

• Supporting Normal Blood Formation and Preventing Certain Types of Anemia

Folate and vitamin B12 work together in normal red blood cell formation. When these vitamins are lacking, bone marrow can produce erythrocytes of abnormal size and reduced functionality.

By ensuring adequate intake from active forms:
✅ Normal red blood cell formation is supported
✅ It contributes to efficient oxygen transport in the body
✅ The risk of developing certain forms of megaloblastic anemia related to folate or B12 deficiency is reduced

This aspect is especially important for vegetarians, vegans, elderly and people with deficient intestinal absorption, category in which B12 deficiency is more frequent.

• Support for Pregnancy, Preconception and Normal Development

Folate is well known for its role in normal fetal neural tube development and in healthy nervous system formation in the first weeks of pregnancy. The L-5-MTHF form is particularly valuable because it is biologically active and does not depend on enzymatic conversion of folic acid, conversion that can be affected in some people.

Although this supplement is not limited to pregnant women, BioActive Folate & Vitamin B12 can:
✅ Support the body during preconception and early pregnancy period (when used at physician's indication)
✅ Contribute to normal cell division and harmonious tissue development
✅ Support maternal folate and B12 reserves, important for mother and fetus

• Supporting Detoxification Processes and Global Methylation

Methylation is also involved in hepatic detoxification processes, in inactivating potentially toxic compounds and in regulating gene expression through DNA methylation.

An efficient methylation cycle, supported by L-5-MTHF and methylcobalamin:
• Helps the body process and eliminate unwanted substances better
• Contributes to epigenetic balance (how genes "express themselves")
• Supports body adaptation to chemical and oxidative stress from surrounding environment

Through all these mechanisms – supporting energy, nervous and cognitive function, balancing homocysteine, normal blood formation, cell division and methylation – BioActive Folate & Vitamin B12, Life Extension emerges as an essential supplement for those who want deep and modern support for metabolism health, nervous system and the entire body.

Directions for Use

Read the entire label and carefully follow the instructions before use.
Take one (1) capsule daily or as recommended by a physician.

Other Ingredients

Microcrystalline cellulose, vegetable cellulose (capsule), dicalcium phosphate.

Warnings