Fisetin 100 mg: Natural Senolytic, Cellular Longevity, Antioxidant Protection and Cognitive Support – Advanced Formula for Healthy Aging and Inflammatory Balance

Fisetin 100 mg, Double Wood Supplements is a premium dietary supplement that provides fisetin 100 mg per serving, a bioactive flavonoid of plant origin, obtained from Cotinus coggygria (stem). Fisetin is intensely studied for its antioxidant and anti-inflammatory properties, but especially for its potential as a natural senolytic – that is, supporting the processes by which the body can reduce the accumulation of senescent cells ("aged cells") that accumulate in tissues with age. These senescent cells no longer divide normally, but remain metabolically active and can secrete pro-inflammatory mediators (a phenomenon known as SASP – senescence-associated secretory phenotype), negatively influencing the tissue microenvironment, the quality of regeneration and the body's inflammatory balance.

In the context of modern longevity, fisetin has become an ingredient of major interest because it is at the intersection of cellular protection, oxidative stress control, mitochondrial function support and maintaining brain health. Oxidative stress and low-grade chronic inflammation are considered two key factors of accelerated aging, and fisetin can contribute to limiting these by modulating inflammatory pathways and neutralizing free radicals. At the same time, research suggests that fisetin can support natural mechanisms of cellular resilience, having a role in maintaining vascular health, metabolic balance and cognitive functions.

Through its concentration of 100 mg and specific botanical source, Fisetin, Double Wood Supplements addresses people seeking advanced support for healthy aging, mental performance, inflammatory balance and systemic antioxidant protection, with emphasis on maintaining tissue quality and cellular function long-term.

Detailed Benefits of Fisetin 100 mg (Cotinus coggygria)

 

• Supporting Processes Associated with Longevity and Senescent Cell Control

One of the most discussed roles of fisetin is its potential to act as a natural senolytic, supporting the processes by which the body can reduce the burden of senescent cells. With advancing age, such cells accumulate in tissues and can disrupt the normal functioning of the body through the secretion of inflammatory signals and factors that affect regeneration.

Fisetin can contribute to:
• supporting the biological "cleaning" of the tissue microenvironment
• maintaining a more balanced inflammatory profile
• supporting long-term tissue quality (skin, vessels, joints)
• favoring functional aging, with better vitality

Through this action, fisetin is often associated with modern longevity strategies that aim not just for "lifespan," but especially healthspan, that is, maintaining the body's functions at an optimal level for as long as possible.

 

• Powerful Antioxidant Protection and Oxidative Stress Reduction

Oxidative stress is the result of an imbalance between the production of free radicals and the body's ability to neutralize them. Free radicals can affect lipids, proteins and DNA, accelerating degenerative processes and amplifying inflammation. As a flavonoid, fisetin has the ability to act as an antioxidant, contributing to the structural protection of cells.

Fisetin supports:
✅ neutralization of free radicals and protection of cell membranes
✅ reduction of lipid peroxidation (a process that degrades cellular lipids)
✅ maintaining DNA integrity against oxidative attacks
✅ supporting the body's endogenous antioxidant capacity

This benefit is relevant both for people exposed to stress, pollution or intense effort, and for those pursuing a long-term prevention strategy, because oxidative stress is a factor involved in multiple mechanisms of aging.

 

• Balancing Inflammatory Response and Support for Joint Comfort

Inflammation is a natural defense mechanism, but when it becomes chronic and persistent it can affect the joints, cardiovascular system, metabolism and brain. Fisetin is studied for its potential to modulate inflammatory pathways and reduce excess pro-inflammatory signals, contributing to a healthier balance.

Through its action, fisetin can help with:
• reducing low-grade inflammation associated with age ("inflammaging")
• supporting mobility and joint comfort in daily life
• maintaining normal connective tissue function
• supporting recovery after effort by optimizing inflammatory response

This support is especially useful for active people, for those who experience stiffness or joint discomfort, but also for those interested in an integrative management of inflammation as a central factor of aging.

 

• Support for Brain Function: Memory, Mental Clarity and Neuroprotection

The brain is particularly vulnerable to oxidative stress due to its high oxygen consumption and high lipid content in neuronal structures. Fisetin is a flavonoid investigated for neuroprotective effects, including supporting processes involved in neuronal plasticity and maintaining cognitive functions.

Fisetin can contribute to:
✅ maintaining mental clarity in demanding periods
✅ supporting memory and learning capacity
✅ protecting neurons from oxidative stress and excessive inflammation
✅ maintaining resilient brain function with age

For people who work intensely intellectually, face chronic stress or desire support for long-term cognitive performance, fisetin is an ingredient of interest, due to its antioxidant profile and inflammation modulation.

 

• Supporting Mitochondrial Health and Energy at the Cellular Level

Mitochondria are the "power plants" of the cell, responsible for energy production (ATP). With age, mitochondrial efficiency can decline, increasing fatigue and vulnerability to metabolic stress. By reducing oxidative stress and influencing cellular protection pathways, fisetin can support a favorable environment for mitochondrial function.

Potential effects include:
• protecting mitochondria against free radicals
• supporting energy production by maintaining cellular integrity
• reducing fatigue associated with oxidative stress and inflammation
• optimizing cellular resilience against stress factors

This type of support is relevant for vitality and performance, especially when the body is exposed to constant demands (intense work, sports, lack of sleep).

 

• Metabolic Support and Maintaining Body Balance Over Time

Metabolism is profoundly influenced by inflammation and oxidative stress. An increased level of inflammation can disrupt insulin sensitivity and energy balance, favoring fat accumulation and energy fluctuations. Through its action of modulating inflammation and cellular protection, fisetin can support a more stable metabolic context.

Fisetin can contribute to:
✅ supporting metabolic balance and efficient nutrient utilization
✅ maintaining physiological response to metabolic stress
✅ protecting tissues involved in energy regulation (liver, muscles, adipose tissue)
✅ promoting an inflammatory profile more favorable to metabolic health

These benefits are all the more important as we age, when the body becomes more sensitive to metabolic imbalances and to the accumulation of oxidative stress effects.

 

• Advanced Cellular Protection and Supporting Regeneration Mechanisms

The body's regeneration depends on the ability of cells to repair themselves and maintain a balanced internal environment. Fisetin, through its antioxidant and anti-inflammatory effects, can support the natural processes by which the body preserves tissue integrity.

Through this support, fisetin can help with:
• maintaining skin health and elasticity (by reducing oxidative stress)
• protecting DNA and cellular structures from daily attacks
• supporting a better adaptive response to environmental factors
• optimizing the functional quality of tissues long-term

Fisetin 100 mg, Double Wood Supplements stands out as a modern supplement oriented toward cellular longevity, with a complex profile of mutually supporting benefits: reducing oxidative stress, balancing inflammation, support for brain and cellular energy, alongside major interest in senescence and healthy aging.

 

Recommended Use:

As a supplement, take 1 capsule per day. For best results, take with a meal.




 

Supplement facts
Serving Size: 1 Capsule
Servings Per Container: 60
	Amount Per Serving	%Daily Value
Fisetin (from Cotinus coggygria) (stem)	100 mg	†
†Daily Value (DV) not established.

 

 

Other Ingredients:

Hypromellose (capsule), Microcrystalline Cellulose, Vegetable Stearate and Silicon Dioxide.



 

WARNING:

Consult a physician before use. Do not use Fisetin if you are pregnant, nursing or under 18 years of age. Discontinue use and consult a physician immediately if adverse reactions occur. Do not use Fisetin and operate heavy machinery until you know how it affects you. Keep out of reach of children. Do not exceed 3 capsules per day.