Name: SAMe (S-Adenosyl-Methionine), 400 mg, Life Extension, 60 Enteric Coated Vegetarian Tablets
Brand: Life Extension
SKU: 3220
Price: 319.99 RON
Availability: InStock

SAMe (S-Adenosyl-Methionine), 200 mg, Life Extension is an advanced dietary supplement that provides S-adenosyl-methionine (SAMe), one of the most important molecules involved in the body's methylation processes. Methylation is a fundamental biochemical mechanism that influences nervous system function, neurotransmitter synthesis and balance, liver metabolism, detoxification and even cell membrane integrity. SAMe is naturally produced in the body from methionine, but levels can be influenced by age, stress, diet, metabolic demands and various imbalances that affect nutrient utilization.

SAMe is known especially for its role in supporting mood and cognitive functions, but also for its importance in joint and liver health. This versatility comes from the fact that SAMe is a major donor of methyl groups, intervening in hundreds of enzymatic reactions. When methylation is efficient, the body can better support the synthesis of substances involved in calm, motivation and mental clarity, can maintain optimal liver function against toxins and can support tissue regeneration processes that influence joint comfort.

In daily life, imbalances associated with chronic stress and overload can appear as irritability, mental fatigue, concentration difficulties, "foggy" state or lack of psychological energy. In parallel, the liver can be burdened by unbalanced diet, polluted environment, medication or periods with excess alcohol or fats. Joints may feel stiffness, discomfort and slower recovery, especially in active people or with advancing age. SAMe is a key molecule that connects these areas through a common basis: the efficiency of methylation reactions and cellular metabolic functioning.

Detailed Benefits of SAMe (S-Adenosyl-Methionine)

Mood is closely linked to the balance of neurotransmitters such as serotonin, dopamine and norepinephrine, but also to how the brain manages stress. SAMe participates in biochemical processes involved in the synthesis and metabolism of these mediators, supporting normal nervous system function.

During demanding periods, the following may appear:
• decreased motivation and mood
• irritability and more intense emotional reactions
• mental fatigue and lack of "drive"

Through methylation support, SAMe can contribute to:
✅ balancing psychological tone and well-being
✅ support for more stable mood throughout the day
✅ better resilience against daily stress

When biochemical processes in the brain are overburdened, concentration difficulties and sensation of "loaded mind" may appear. Methylation also influences the synthesis of membrane phospholipids and neuronal metabolism, elements that can support the efficiency of communication between nerve cells.

SAMe can support:
✅ mental clarity and focus capacity
✅ support for cognitive functions during stress periods
✅ maintaining more constant mental rhythm, without "drops" in the second part of the day

SAMe is frequently associated with joint health because it participates in reactions involved in the synthesis of structural compounds and in maintaining inflammatory balance. Joints are daily exposed to microtrauma, effort, static postures and oxidative stress. When recovery mechanisms are slow, stiffness and discomfort may appear, especially in the morning or after intense activities.

In joint context, SAMe can contribute to:
✅ support for joint comfort and flexibility
✅ maintaining functional mobility in active people
✅ support for recovery after repeated physical demands

The liver is the central organ for detoxification, fat metabolism and management of substances from diet and environment. Methylation is essential for liver processes such as glutathione synthesis (a major antioxidant), metabolism of certain hormones and neutralization of reactive compounds.

When the liver is overburdened, the following may appear:
• sensation of general fatigue without clear reason
• heavier digestion after rich meals
• increased sensitivity to dietary excesses

SAMe can support:
✅ liver detoxification processes and metabolic balance
✅ antioxidant protection and cellular resilience to oxidative stress
✅ body's capacity to manage modern metabolic "load"

Methylation influences numerous functions: gene expression, creatine synthesis, neurotransmitter metabolism, liver function and cell membrane integrity. A body with efficient methylation tends to manage stress better, support more stable energy levels and maintain coherent metabolic functions.

SAMe, as a major methyl donor, can contribute to:
✅ support for enzymatic reactions essential for body balance
✅ maintaining cellular function under stress and demand conditions
✅ integrated metabolic support for multiple systems (nervous, hepatic, musculoskeletal)

Glutathione is one of the most important endogenous antioxidants, involved in protecting cells against oxidative stress. SAMe is indirectly connected with this area through its role in sulfur and methylation metabolic cycles, processes that support the body's capacity to maintain antioxidant defense.

This support can be relevant for:
✅ periods of fatigue associated with increased oxidative stress
✅ urban lifestyle, variable diet, exposure to pollutants
✅ long-term support for cellular "resilience"

One of the most important advantages of SAMe is that it does not act "isolated" on a single symptom, but supports a basic process that influences multiple health areas. For people seeking a supplement with solid biochemical logic, SAMe is an interesting option precisely because of its central role in methylation.

Through this approach, SAMe can support:
✅ more balanced mood and psychological tone
✅ joint comfort and functional mobility
✅ liver function and metabolic detoxification
✅ cellular protection and resilience to modern stress

Directions for Use

For joint support: take one (1) tablet six times daily, in divided doses, preferably on an empty stomach, or as recommended by a healthcare professional.
For mood support: take one (1) tablet eight times daily, in divided doses, preferably on an empty stomach, or as recommended by a healthcare professional.
Administer together with cofactor vitamins B12, B6 and folic acid.

Other Ingredients

Cellulose, mannitol, methacrylic acid copolymer, citric acid, stearic acid, silica, hypromellose, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, calcium carbonate, yellow ocher.

Warnings

SAMe should not be administered to those diagnosed with bipolar disorder.
Store in a cool, dry place.
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if foil is damaged.
Consult your physician if you are undergoing treatment for a medical condition or if you are pregnant or nursing.

Supplement Facts
Serving Size: 1 enteric coated vegetarian tablet
	Amount Per Serving	% DV
S-adenosyl-methionine	200 mg	**
**Daily Value not established.

SAMe (S-Adenosyl-Methionine), 400 mg, Life Extension, 60 Enteric Coated Vegetarian Tablets

SAMe (S-Adenosyl-Methionine), 200 mg: Balanced Mood, Joint Support, Liver Detoxification and Cellular Methylation – Essential Cofactor for Neurotransmitters and Liver Function

Detailed Benefits of SAMe (S-Adenosyl-Methionine)

Support for Balanced Mood and Emotional Resilience

Support for Mental Clarity, Concentration and Cognitive Performance

Joint Support and Maintenance of Mobility Comfort

Support for Liver Function and Metabolic Detoxification

Optimization of Methylation: Fundamental Mechanism for Systemic Health

Cellular Protection and Antioxidant Balance Through Role in Glutathione Synthesis

Balance-Oriented Approach: Same Molecule, Benefits in Multiple Directions

Directions for Use

Other Ingredients

Warnings

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