SAMe 200, 200 mg – Emotional Balance, Liver Health and Joint Support – Advanced Supplement with S-Adenosylmethionine for Methylation, Detoxification and Mental Vitality

SAMe 200, 200 mg, Jarrow Formulas is a premium dietary supplement that contains S-adenosylmethionine (SAMe), a natural compound normally produced by the body from essential amino acid methionine and ATP. SAMe is involved in hundreds of essential biochemical reactions, having a central role in methylation processes, in neurotransmitter synthesis, in supporting liver health, in emotional balance and in joint comfort.

Methylation is a fundamental process by which the body activates or deactivates molecules, regulates gene expression, detoxifies harmful substances, produces phospholipids for cell membranes and synthesizes essential compounds for proper nervous system function. SAMe is considered one of the main methyl group donors in the body, participating in formation of serotonin, dopamine, norepinephrine, phosphatidylcholine and other important mediators.

As the body is subjected to chronic stress, unbalanced diet, alcohol consumption or liver conditions, natural SAMe level can decrease, which affects both emotional state and liver function, metabolism and general state of vitality. Through supplementation with SAMe 200 mg, the body receives direct support for these essential processes, contributing to supporting balanced mood, healthy liver, joints and nervous system.

Detailed Benefits of SAMe (S-adenosylmethionine)

• Supporting Emotional Balance and Mental Wellbeing

One of the best-known benefits of SAMe is related to support offered for emotional mood and psychological tone. SAMe is involved in neurotransmitter synthesis:
• serotonin – associated with wellbeing and relaxation
• dopamine – linked to motivation, pleasure and mental energy
• norepinephrine – involved in alertness and stress adaptation capacity

Through its role as methyl group donor, SAMe:
✅ contributes to synthesis and balance of these neurotransmitters
✅ supports stable emotional mood
✅ supports the body's ability to manage daily stress

This effect makes SAMe useful for people who want to support their psychological tone, mental clarity and general wellbeing, in the context of a demanding lifestyle.

• Support for Liver Health and Detoxification Processes

The liver is the central organ of detoxification, and SAMe plays a key role in hepatic metabolism. SAMe participates in:
• glutathione synthesis – the liver's main intracellular antioxidant
• transmethylation and transsulfuration reactions – involved in neutralizing and eliminating toxins
• maintaining liver cell membrane fluidity

Through these mechanisms, SAMe:
✅ supports optimal liver cell function
✅ contributes to liver protection against oxidative stress and aggressive factors
✅ helps natural processes of purifying harmful substances from the body

SAMe 200, Jarrow Formulas can thus be an important ally for people who want to support their liver health, especially in the context of exposure to pollutants, unhealthy eating habits or demanding lifestyle.

• Supporting Joint Comfort and Mobility

Joint health depends on cartilage and connective tissue integrity, as well as inflammatory process balance. SAMe is involved in synthesis of cartilage structural compounds, such as proteoglycans and certain components of extracellular matrix.

Through its metabolic role, SAMe can:
✅ support regeneration and maintenance of articular cartilage structure
✅ contribute to maintaining joint flexibility and comfort
✅ support mobility in daily activities

These effects make it suitable for people who want to maintain their joint comfort and functionality, whether they lead an active lifestyle or aim to protect their mobility with advancing age.

• Essential Role in Methylation and Cellular Health

Methylation is one of the most important biochemical processes in the body, influencing:
• gene expression
• DNA repair
• neurotransmitter synthesis
• detoxification and neutralization of potentially harmful compounds

SAMe is the main methyl group donor in numerous methylation reactions. Through this role, SAMe:
✅ contributes to fine regulation of cellular processes
✅ supports DNA stability and normal function
✅ helps maintain balanced metabolic activity

An efficient methylation process is essential for maintaining long-term health, for stress adaptation and for optimal nervous system and liver function.

• Supporting Nervous System and Cognitive Functions

Besides mood influence, SAMe has an important role in nervous system structure and function. Through participation in phospholipid synthesis (such as phosphatidylcholine) and fatty acids in neuronal membranes, SAMe:
• contributes to nerve cell membrane integrity and fluidity
• supports efficient nerve impulse transmission
• supports communication between neurons in different brain regions

The result is:
✅ supporting mental clarity and concentration
✅ support for memory and cognitive processes
✅ maintaining general nervous system health

• Support for Homocysteine Metabolism and Cardiovascular Health

Homocysteine is an intermediate amino acid in methionine metabolism, and elevated homocysteine levels are associated with increased cardiovascular risk. SAMe is involved in the methionine-homocysteine cycle, through methylation reactions that help transform homocysteine back into methionine or other beneficial compounds.

Through this metabolic role, SAMe:
✅ contributes to maintaining balanced homocysteine level (in association with other cofactors, such as folate and B vitamins)
✅ supports blood vessel health
✅ offers indirect support to cardiovascular system, through correct metabolic processes

• Support for Energy and General Vitality

Beyond specific effects on liver, joints and nervous system, SAMe participates in numerous biochemical reactions that impact general vitality state. Through its role in:
• synthesis of neurotransmitters responsible for motivation and mental energy
• supporting liver function and detoxification
• regulating methionine metabolism and other amino acids

SAMe 200, Jarrow Formulas can:
✅ support sensation of energy and general tone
✅ contribute to reducing fatigue states associated with metabolic overwork
✅ support global feeling of wellbeing, balance and optimal body function

Through all these effects, SAMe 200 (S-adenosylmethionine), 200 mg, Jarrow Formulas stands out as a complex supplement, oriented toward supporting emotional balance, liver health, joint comfort, nervous system and methylation processes, contributing to a state of vitality and harmonious body function at cellular level.

Directions for Use

Adults take 1 tablet 1 or 2 times daily on an empty stomach or as directed by qualified healthcare professional.

Other Ingredients

Microcrystalline cellulose, mannitol, coating (hypromellose acetate succinate, stearic acid [vegetable source], triethyl citrate, riboflavin), glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide and sodium starch glycolate. 
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame. 

Warnings

Do not use if pregnant or nursing. People with Parkinson's disease, bipolar disorder or manic depression should not use this product. May cause gastrointestinal upset in some people. Consult a healthcare professional before using this product if you are under 18 years of age, taking medications (antidepressants, selective serotonin reuptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use.
Keep out of reach of children.
Store in a cool, dry place.
Do not use if safety seal or blister are broken, damaged or missing.