Calcium D-Glucarate – Advanced Liver Detoxification, Hormonal Balance and Cellular Health – Support for Estrogen Metabolism and Toxin Elimination

Calcium D-Glucarate 500 mg, NOW Foods is designed to support Phase II detoxification, hormonal balance (especially estrogen metabolism), cellular protection and daily metabolic clarity. The formula delivers Calcium D-Glucarate (tetrahydrate) – 500 mg per serving, also providing Calcium (from Calcium D-Glucarate) – 60 mg (5%), so that the body benefits from the key mechanism of glucuronidation – one of the most important hepatic conjugation pathways for neutralizing and excreting endogenous and exogenous compounds. By supporting this natural route, Calcium D-Glucarate supports a more balanced hormonal profile, a reduced toxic load and a coherent metabolic tone.

Detailed Benefits of Calcium D-Glucarate

• Supporting Liver Detoxification (Phase II – Glucuronidation)

Efficient detoxification involves conjugating "used" or potentially reactive compounds to make them water-soluble and easy to eliminate. The glucuronidation pathway attaches a glucuronic "tag" to these compounds, facilitating their biliary and renal excretion.

✅ Supports the neutralization and elimination of endogenous substances (hormones, metabolites) and exogenous ones (xenobiotics, pollutants);
✅ Contributes to easing the liver burden, helping the liver maintain an orderly metabolic flow;
✅ Promotes a cleaner internal profile, reflected in better energy and general state.
By supporting this pathway, Calcium D-Glucarate becomes a pillar for daily metabolic hygiene.

• Hormonal Balance Through Supporting Estrogen Metabolism

The body recirculates some estrogens, and managing this recirculation influences hormonal balance. Calcium D-Glucarate supports estrogen conjugation and elimination of inactive forms, helping maintain a harmonized estrogenic profile.

✅ Contributes to healthy estrogen metabolism;
✅ Supports avoiding excessive recirculation through the enterohepatic pathway;
✅ Helps with mood stability and comfort associated with hormonal variations.
This discreet but important action translates into a more stable hormonal tone in daily life.

• Beta-Glucuronidase Inhibition – Protecting Conjugates for Excretion

An enzyme called beta-glucuronidase can "break" glucuronic bonds, risking deconjugation and recirculation of compounds that were meant to be eliminated. Calcium D-Glucarate supports tempering beta-glucuronidase activity, keeping conjugates stable until excretion.

✅ Supports completion of the detoxification process without "backward steps";
✅ Contributes to reducing recirculation of unwanted metabolites;
✅ Promotes more efficient metabolic clearance.
The result is a coherent detox line, with fewer "leaks" back into the systemic flow.

• Metabolic Clarity and Daily Energy

When elimination pathways function smoothly, the body allocates fewer resources to "firefighting" metabolic issues. This efficiency feels like systemic lightness and constant vitality.

✅ Supports a feeling of lightness and mental clarity;
✅ Contributes to more stable energy throughout the day;
✅ Promotes resilience during busy periods.
Metabolic clarity helps with focus and a balanced overall tone.

• Digestive Comfort and Balanced Enterohepatic Flow

Some conjugates are eliminated through bile and intestinal transit; a harmonized biliary flow and digestive rhythm complement detoxification.

✅ Supports an intestinal dynamic friendly to excretion;
✅ Contributes to reduced digestive discomfort associated with stagnation;
✅ Helps with consistency of eliminations.
This practical link anchors the benefits at the level of the daily digestive routine.

• Cellular Protection and Redox Balance

Reducing the load of reactive compounds decreases pressure on antioxidant systems. When "metabolic waste" is evacuated orderly, the oxidative stress perceived by cells can be lower.

✅ Supports cellular tone and integrity;
✅ Contributes to a balanced redox state;
✅ Helps with cellular aging in a more harmonious context.
This cellular protection forms the foundation for sustained vitality.

• Synergy with Other Detox and Hormonal Support Pathways

Calcium D-Glucarate supports Phase II detoxification, but it works optimally when integrated with a balanced diet, hydration, quality sleep and a healthy microbiome.

✅ Fiber from vegetables supports biliary elimination;
✅ Cruciferous vegetables (broccoli, cabbage) provide indole-3-carbinol for hormonal support;
✅ Adequate hydration supports renal elimination;
✅ A balanced intestinal flora reduces beta-glucuronidase activity.
This multidimensional synergy creates a complete detox environment.

• Scientific Evidence and Mechanism of Action

Research indicates that D-glucarate supports glucuronidation by providing a substrate analog that inhibits beta-glucuronidase.

✅ Clinical studies explore benefits in estrogen metabolism;
✅ Data suggest potential for supporting liver health during toxic challenges;
✅ The convergence of preclinical and clinical research supports the biological rationale.
Evidence is constantly evolving, but the mechanism is well-defined and scientifically grounded.

• Who Benefits Most from Calcium D-Glucarate

• People seeking support for liver health and detoxification;
• Women with concerns about hormonal balance and estrogen metabolism;
• Those exposed to urban pollutants, processed foods, or experiencing digestive stress;
• Individuals looking for support for cellular protection and redox balance;
• Fitness enthusiasts seeking metabolic clarity and sustained energy;
• Anyone building a detoxification routine integrated with nutrition and lifestyle;
• Users interested in clarity, stable energy and digestive comfort;
• Anyone building a metabolic hygiene routine oriented on prevention and balance.

• How It Feels in Daily Life

Common feedback describes:
✅ Systemic lightness and more coherent vitality;
✅ Increased mental clarity on the basis of better "internal cleanliness";
✅ Digestive comfort and more predictable elimination rhythm;
✅ A general state of balance that supports focus and discipline throughout the day.
Effects are gradual, but visible as the elimination pathway stabilizes.

• Why Calcium D-Glucarate from NOW Foods

NOW Foods delivers a focused formula: 500 mg Calcium D-Glucarate accompanied by 60 mg calcium, a dosage targeting glucuronidation support and beta-glucuronidase inhibition, two levers that work together to maintain detox flow. The brand's reputation for standardization, testing and traceability provides confidence that you receive a consistent amount and quality with each use.

Calcium D-Glucarate 500 mg, NOW Foods, is a modern metabolic tool: it supports the liver, helps with estrogen metabolism, supports efficient elimination of compounds and encourages a balanced cellular tone. For a daily routine oriented on clarity, balance and lightness, it's an intelligent, simple and precise choice.




 

Directions for Use

Take 1 capsule 3 times per day.




 

Other Ingredients

Cellulose (capsule), Cellulose Powder and Stearic Acid (vegetable source).
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.
Produced in a GMP facility that processes other ingredients containing these allergens.

Warnings

Store in a cool, dry place after opening.
Caution: For adults only. Do not take if pregnant/nursing. Consult physician if taking medication or have a medical condition. Keep out of reach of children.
Do not eat freshness packet. Keep in bottle.
Natural color variation may occur in this product.