Methyl Folate (5-MTHF) 400 mcg– Healthy Methylation, Homocysteine Balance, Cellular Energy and Cognitive Function Support

Methyl Folate (5-MTHF) 400 mcg, Jarrow Formulas, offers bioactive folate form: ((6S)-5-methyltetrahydrofolate, stabilized as glucosamine salt, for superior bioavailability and direct body utilization. Each serving provides Folate 400 mcg (as (6S)-5-MTHF from glucosamine salt), equivalent to 680 mcg DFE (Dietary Folate Equivalents), i.e. 170% of daily reference value. Unlike ordinary folic acid, 5-MTHF doesn't require extensive enzymatic conversions and can be used immediately in critical methylation reactions, DNA/RNA synthesis and homocysteine metabolism. Through its role in "one-carbon" cycle, 5-MTHF contributes to hematopoiesis, cognitive function support and maintaining balanced metabolic profile, offering coherent support for energy, mental clarity and daily vitality.

Detailed Benefits of Methyl Folate (5-MTHF)

• Efficient methylation and homocysteine balance

Methylation is fundamental biochemical process for gene expression, neurotransmitter synthesis and reactive intermediate detoxification. 5-MTHF is direct methyl group donor in homocysteine to methionine conversion, supporting:

✅ Maintaining healthy homocysteine level
✅ Methionine regeneration and S-adenosyl-methionine (SAMe) production
✅ Metabolic framework favorable to well-being and cardiovascular function
Through its increased availability, (6S)-5-MTHF optimizes these reactions even in contexts where folic acid conversion might be limited.

• DNA/RNA synthesis and cell division

Folate is indispensable for genetic material replication and repair. 5-MTHF participates in purine and pyrimidine formation, facilitating:

✅ Normal cell division in tissues with rapid turnover
✅ Growth processes, tissue regeneration and cellular integrity maintenance
✅ Coherent enzymatic profile for nucleotide biogenesis
This molecular support is reflected in overall vitality and body's ability to adapt and recover.

• Hematopoiesis and tissue oxygenation

Together with vitamin B12, folate supports erythropoiesis. 5-MTHF contributes to:
✅ Normal red blood cell formation
✅ Efficient oxygen transport to tissues
✅ Reducing fatigue sensation associated with suboptimal folate status
Through support provided to hematopoietic cells, body maintains more stable energy rhythm throughout the day.

• Supporting cognitive functions and mental clarity

Methylation influences neurotransmitter synthesis (e.g., dopamine, serotonin, norepinephrine). 5-MTHF, as methyl donor, helps with:

✅ Mental clarity, attention and focus
✅ Balanced mood, especially in demanding periods
✅ Neurocognitive response coherence to prolonged tasks
Optimal neuronal metabolism needs adequate methyl flow, and 5-MTHF provides this essential biochemical "currency".

• Cellular energy and metabolic resilience

Although folate isn't stimulant, its role in one-carbon cycle indirectly influences energy production through support for nucleotide synthesis and methionine/SAMe regeneration. Result is:
✅ "Cleaner" metabolic flow in anabolic processes
✅ Increased efficiency in daily tasks and high-workload periods
✅ Coherent vitality sensation, without abrupt fluctuations
By maintaining cellular process integrity, 5-MTHF supports stable energy performance.

• Bioactive form, ready to use (compatible with conversion sensitivities)

Some people have genetic variants at MTHFR enzyme level, which can diminish folic acid to 5-MTHF conversion. Choosing (6S)-5-MTHF form:

✅ Bypasses conversion limiting steps
✅ Ensures immediate availability in methylation reactions
✅ Offers metabolic response consistency between individuals
This approach eliminates uncertainties related to variable enzymatic transformations.

• Stability and bioavailability through glucosamine salt

Jarrow Formulas uses 5-MTHF stabilized as glucosamine salt, which:
✅ Increases ingredient stability over time
✅ Promotes absorption and systemic utilization
✅ Ensures predictable bioactive folate delivery
This technology is appreciated for consistency with which it delivers folate in form desired by body.

• Synergy with methylation axis (B12, B6, choline, betaine)

5-MTHF is at center of nutrient "ecosystem" involved in methylation. In this context, 5-MTHF:
✅ Potentiates homocysteine conversion and supports methyl balance
✅ Integrates one-carbon flows with methionine-SAMe cycle
✅ Contributes to biochemical architecture of neurotransmitter synthesis
This synergy explains why active folate form is preferred in formulas oriented toward methylation and mental performance.

• Supporting cardiovascular health through homocysteine control

Maintaining homocysteine within normal parameters is important metabolic objective. 5-MTHF:
✅ Provides methyl needed for homocysteine re-methylation
✅ Supports endothelial integrity through balanced metabolic environment
✅ Contributes to coherent cardiovascular profile
This support adds to benefits on energy, mental clarity and hematopoiesis.

• Skin comfort, hair and nails through cellular turnover support

Tissues with rapid division depend on folate availability for DNA/RNA synthesis. 5-MTHF:
✅ Supports skin cellular renewal
✅ Contributes to harmonious growth rhythm for hair and nails
✅ Promotes tissue trophicity maintenance
By ensuring genetic "bricks", body preserves its natural renewal processes.

• Clean profile, intelligent dosing and nutritional value traceability

With 400 mcg 5-MTHF per serving (equivalent 680 mcg DFE, 170%), Jarrow formula:
✅ Offers transparency about folate equivalents (DFE)
✅ Delivers bioactive form in quantity suitable for daily use
✅ Prioritizes quality, stability and lot-to-lot consistency
This clarity is essential for maintaining balanced nutritional routine.

• Versatile for modern lifestyle

Intense rhythms, study periods or demanding projects require metabolic coherence. 5-MTHF:
✅ Supports cognitive performance and mental well-being
✅ Contributes to stable cellular energy through methylation architecture
✅ Accompanies routines oriented toward vitality and productivity
Thus, biochemical foundation conducive to concentration, resilience and constant rhythm throughout the day is created.

Methyl Folate (5-MTHF) 400 mcg, Jarrow Formulas, brings together power of bioactive folate form – (6S)-5-MTHF – with excellent bioavailability and clear nutritional traceability (680 mcg DFE, 170%), to support methylation, homocysteine balance, DNA/RNA synthesis, hematopoiesis and cognitive functions. Through integration into one-carbon cycle, 5-MTHF helps maintain robust metabolism, daily energy and visible mental clarity, aligning with modern lifestyle needs.

Directions for Use

Adults take 1 capsule once daily, with or without food or as directed by qualified healthcare professional.

Other Ingredients

Microcrystalline cellulose capsule (hydroxypropylmethylcellulose, water) and magnesium stearate (vegetable source).
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.

Warnings

Consult healthcare professional before using this product if you are pregnant, nursing, under 18 years of age, taking medication (especially antiepileptic or chemotherapy drugs) or have medical condition; if adverse reactions occur, discontinue use.
Keep out of reach of children.
Do not use if safety seal is damaged or missing.
Store in cool, dry place.