Experience Enhanced Folate Absorption and Amplified Health Benefits with Quatrefolic, Vitamin B9 supplement in active form.

Doctor's Best Fully Active Folate 800 with Quatrefolic is a dietary supplement that provides a highly bioavailable form of folate, a B vitamin essential for many bodily functions. Folate plays a critical role in DNA synthesis, cell division and red blood cell production. It is particularly important during pregnancy for the proper development of the foetus.

The key feature of this product is the use of Quatrefolic, which is a patented form of 5-MTHF (5-methyltetrahydrofolate). 5-MTHF is the active, naturally occurring form of folate that is easily utilized by the body. Unlike synthetic folic acid, which must be converted by the body to its active form, 5-MTHF is already in a bioavailable form, making it easier to use by people with genetic variations that affect folic acid metabolism.


 

Methyl Folate with Quatrefolic Benefits

 

• DNA synthesis and cell division:

Folate is essential for the synthesis and repair of DNA, our genetic material. It is especially important during periods of rapid cell division, such as fetal development and growth, childhood and adolescence. Folate helps produce and maintain new cells.
 

• Formation of red blood cells:

Folate is involved in the production of red blood cells. It plays a vital role in the formation of haemoglobin, the protein in red blood cells that carries oxygen throughout the body. A deficiency of folate can lead to a type of anaemia called megaloblastic anaemia, characterised by larger than normal red blood cells that are not fully functional.
 

• Homocysteine metabolism:

Folate is involved in the conversion of homocysteine, an amino acid, to methionine. High levels of homocysteine in the blood have been associated with an increased risk of cardiovascular disease. Adequate folate intake helps maintain healthy homocysteine levels, thereby promoting cardiovascular health.
 

• Neural tube development:

Folate is of greatest importance during pregnancy, especially in the early stages when the neural tube is forming. Adequate folate intake before conception and early in pregnancy helps reduce the risk of neural tube defects such as spina bifida and anencephaly, which affect brain and spinal cord development in the foetus.
 

• Mental and emotional health:

Folate is involved in the production of neurotransmitters, which are chemicals that transmit signals in the brain. It plays a role in the synthesis of serotonin, dopamine and noradrenaline, which are important for mood regulation. Low folate levels have been associated with an increased risk of depression and cognitive decline.


 

What is the difference between Folic Acid and Folate?

Folic acid and folate are both forms of vitamin B9, but they differ in their chemical structure and the way they are used by the body.
 

• Folate:

Folate is the naturally occurring form of vitamin B9 found in food. It is an umbrella term that encompasses various forms, including 5-methyltetrahydrofolate (5-MTHF), which is the active form of folate. Folate is naturally present in foods such as leafy green vegetables, pulses, fruit and fortified cereal products.
 

• Folic acid:

Folic acid, on the other hand, is the synthetic form of vitamin B9. It is created through chemical processes and is commonly used in dietary supplements. Folic acid is more stable and less likely to degrade during processing and storage compared to natural folate.

The main difference between folate and folic acid lies in the way they are metabolised in the body. Folate is already in the active form and can be used directly by the body without any further processing. Folic acid, however, has to go through several enzymatic transformations in the body to be converted into its active form, 5-MTHF, before it can be used effectively.

The conversion of folic acid to 5-MTHF involves the enzyme dihydrofolate reductase (DHFR) and other enzymatic reactions. Some people may have genetic variations or factors that affect the efficiency of this conversion process, leading to reduced folic acid utilisation and a potential accumulation of unmetabolised folic acid in the blood.



 

What is Quatrefolic?

Quatrefolic is a registered trademark of 5-methyltetrahydrofolate (5-MTHF), which is the active and bioavailable form of folate, also known as vitamin B9. It is produced by Gnosis, an Italian company specialising in the development of innovative nutritional ingredients.

Quatrefolic is designed to provide a more stable and bioavailable form of folate compared to traditional folic acid supplements. It is derived from a naturally occurring form of folate and is structurally identical to 5-MTHF found in food. This form of folate does not require additional enzymatic conversion in the body to be used effectively.

Quatrefolic's advantage lies in its stability and its ability to directly supply the active form of folate. It remains stable during processing and storage, making it suitable for use in dietary supplements. Its use is particularly beneficial for people who have difficulty converting folic acid to its active form or who need higher levels of folic acid due to specific health conditions or life stages, such as pregnancy.



 

Suggested use

Take 1 capsule daily, preferably between meals, or as recommended by a nutritionally-informed physician.

 

Other ingredients

Microcrystalline cellulose, modified cellulose (vegetarian capsule).

Warnings

Store in a cool, dry place.