Methylfolate BioCoenzymated: Efficient Methylation, Cardiovascular Health, Mental Balance and Cellular Energy – Premium Support for Optimal Body Function

BioCoenzymated™ Methylfolate 1,000 mcg, from Natural Factors, is an advanced dietary supplement, formulated with the most active form of folate – (6S)-5-methyltetrahydrofolate (MTHF) – as glucosamine salt (Quatrefolic®), synergistically combined with vitamin B12 as methylcobalamin. This innovative combination supports homocysteine metabolism, efficient methylation, red blood cell formation, normal nervous system development and healthy brain function.
 

Unlike synthetic folic acid, which requires multiple metabolic conversions to become active in the body, MTHF (methylfolate) is the biologically active form of folate, immediately available for cellular use. Thus, it is ideal for people with MTHFR genetic mutations or other metabolic deficiencies that prevent efficient conversion of folic acid to its active form. The combination with methylcobalamin – the active form of vitamin B12 – ensures complete support for DNA synthesis, cell division, mental balance and energy production.



 

Detailed Benefits of Methylfolate BioCoenzymated™ with B12 Methylcobalamin

• Supporting Cellular Methylation – Essential Process for General Health

Methylation is a fundamental biochemical process that occurs in every body cell and influences numerous biological functions, including:

• DNA and RNA synthesis

• Gene expression regulation

• Detoxification of harmful compounds

• Neurotransmitter formation (serotonin, dopamine, noradrenaline)

To function efficiently, the methylation process requires adequate intake of methyl group donors, including methylfolate (MTHF) and methylcobalamin. Lack of these cofactors leads to deficient methylation, with possible consequences:

• Mood disorders (anxiety, depression)

• Chronic fatigue

• Hormonal and neurological disorders

• Increased sensitivity to toxins and oxidative stress

By providing these nutrients in their active form, BioCoenzymated™ Methylfolate supports:
✅ Efficient methylation, essential for epigenetic balance
✅ Liver detoxification and reducing homocysteine accumulation
✅ Neurotransmitter production that regulates mood

• Reducing Homocysteine Levels – Cardiovascular Protection

Homocysteine is an amino acid naturally produced in the body, but in high concentrations it can become harmful, promoting:

• Vascular inflammation

• Atherosclerotic plaque formation

• Increased risk of cardiovascular disease, stroke and thrombosis

Active folate and vitamin B12 play an essential role in converting homocysteine to methionine, a methylation-dependent reaction. Deficiencies in methylfolate or methylcobalamin frequently lead to:

• Hypermethioninemia and hyperhomocysteinemia

• Endothelial lesions and blood vessel stiffening

• Impaired peripheral and cerebral circulation

Through BioCoenzymated™ Methylfolate supplementation:
✅ Blood homocysteine levels are normalized
✅ Vascular inflammation and coronary disease risk are reduced
✅ Heart and circulatory system health are protected

• Improving Cognitive Function and Mental Health

Folate and vitamin B12 in active form are essential for synthesis and balance of brain neurotransmitters:

• Serotonin (mood regulation)

• Dopamine (motivation and pleasure)

• Noradrenaline (concentration and vigilance)

Deficiencies in methylfolate or methylcobalamin can lead to:

• Chronic depression, anxiety, irritability

• Concentration and memory difficulties

• Increased risk of cognitive decline in elderly

Through bioactive intake from BioCoenzymated™ formula, one obtains:
✅ Support for mental health and emotional well-being
✅ Supporting neurochemical processes of synaptic transmission
✅ Reducing depression risk, especially in people with MTHFR polymorphism

• Support for Pregnancy and Healthy Fetal Development

Methylfolate is one of the most important substances for pregnancy, being essential for:

• Cell division and fetal nervous system development

• Preventing neural tube defects (spina bifida, anencephaly)

• Normal placenta formation and fetal vascularization

Unlike synthetic folic acid, methylfolate from BioCoenzymated™:
✅ Is directly available for cellular use, without intermediate enzymatic steps
✅ Is better absorbed and tolerated by women with MTHFR mutations
✅ Provides superior neurodevelopmental protection in pregnancy

• Red Blood Cell Formation and Preventing Megaloblastic Anemia

Both folate and vitamin B12 are vital for DNA synthesis and erythrocyte formation in bone marrow. Deficiencies of these vitamins can cause:

• Megaloblastic anemia (immature, large red blood cells)

• Severe fatigue and weakness

• Breathing difficulties and dizziness

Through daily administration of BioCoenzymated™ Methylfolate:
✅ Normal red blood cell formation is supported
✅ Anemia associated with folate/B12 deficiencies is prevented
✅ Oxygen transport to tissues is improved

• Supporting Cellular Energy and Combating Chronic Fatigue

Methylfolate and methylcobalamin directly contribute to energy metabolism through:

• Converting homocysteine to methionine and then SAMe – an important methyl donor

• Participating in folate cycle, essential for ATP synthesis

• Protecting mitochondria and reducing oxidative stress

People with low B9/B12 levels frequently experience:

• Physical exhaustion, lack of motivation

• Excessive daytime sleepiness

• Lack of concentration and poor performance

BioCoenzymated™ contributes to:
✅ Restoring mitochondrial energy metabolism
✅ Increasing daily energy levels and endurance
✅ Optimal functioning of high energy-consuming systems (muscular, nervous, cardiac)

• Support for Liver Detoxification and Cellular Health

Methylfolate is involved in glutathione synthesis – the most important intracellular antioxidant – by supporting the methionine-cysteine cycle. This contributes to:

• Neutralizing free radicals and toxins

• Regulating inflammatory processes

• Preventing cellular deterioration and genetic mutations

By maintaining optimal levels of methylfolate and B12, one obtains:
✅ Efficient liver detoxification
✅ Supporting cellular integrity and DNA protection
✅ Reducing systemic oxidative stress

BioCoenzymated™ Methylfolate from Natural Factors is a next-generation supplement, designed for people seeking an efficient source of active folate and methylated vitamin B12, to support methylation, energy, cardiovascular, mental and cellular health. Combining Quatrefolic® technology with methylcobalamin, this formula offers rapid absorption, increased tolerance and superior therapeutic efficiency.



 

Suggested Use

Chew or dissolve 1 tablet daily in mouth before swallowing or as directed by a healthcare professional.




 

Other Ingredients

Lactose, microcrystalline cellulose, croscarmellose sodium, ‡farm fresh factors™, magnesium stearate (vegetable grade).

‡Active vegetables – organic cabbage, organic alfalfa, organic coriander leaves, organic parsley, rose hips, sprouted garlic, organic artichoke, organic black radish, organic dandelion, barley grass, pepper, organic celery seeds, organic red beet, organic tomatoes; Cruciferous vegetables – a broad spectrum of fully active glucosinolates and myrosinase enzymes from wasabi rhizome (Wasabia japonica) and fresh sprouted freeze-dried broccoli, organic watercress, daikon, red radish, organic cauliflower, organic cabbage, organic arugula, organic cress leaves; Ultra Fruit Polyphenols – grapes, pomegranate, strawberries, organic blueberries, raspberry, bilberry, blueberries, organic cranberry, schizandra berries, red oranges, organic acai berries; Herbs and plants – Theracurmin® curcumin, organic decaffeinated green tea extract, organic ginger rhizome, organic echinacea, organic oregano, organic peppermint, organic spearmint; Whole sea vegetables – organic spirulina, organic chlorella, red algae, blue-green algae, kelp algae.

Contains milk.

Contains no artificial colors, preservatives or sweeteners; no starch, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts or GMOs.

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Warnings

As with any supplement, consult your physician before use if you are pregnant, nursing or trying to conceive or if you are taking medications, have a medical condition or anticipate a surgery. Keep out of reach of children.

Sealed for your protection. Do not use if seal is broken. For freshness, keep in a cool, dry place.