Citrus Bioflavonoids Plus Hesperidin: Vascular Health, Immunity and Antioxidant Protection – Natural Citrus Complex for Vitality and Systemic Balance

Citrus Bioflavonoids Plus Hesperidin, 650 mg, by Natural Factors is an advanced supplement formulated based on a standardized extract of citrus bioflavonoids and hesperidin, obtained from citrus fruit peels such as lemon (Citrus limon), orange (Citrus sinensis), grapefruit (Citrus paradisi), mandarin (Citrus reticulata) and lime (Citrus aurantifolia). With a concentration of 500 mg of citrus bioflavonoids and 150 mg of hesperidin, this product offers exceptional synergistic support for capillary health, antioxidant protection, immune function and inflammatory balance.
 

Bioflavonoids are polyphenolic compounds found naturally in citrus fruits and are known for their ability to strengthen blood vessel walls, support circulation and protect cells against oxidative stress. In combination with hesperidin – a specific flavonoid from sweet oranges – the supplement becomes an essential ally for cardiovascular health, capillary resistance, chronic inflammation and prevention of immune imbalances.

Detailed Benefits of Citrus Bioflavonoids Plus Hesperidin

• Supporting vascular health and reducing capillary fragility

One of the most well-known effects of citrus bioflavonoids is strengthening vascular walls and supporting peripheral circulation. Capillary fragility is a common problem especially among elderly people, women suffering from varicose veins or those with predisposition to bruising and edema.

Flavonoids act by:

✅ Consolidating the vascular wall – reducing excessive capillary permeability
✅ Improving venous tone – preventing venous stasis and fluid accumulation
✅ Increasing vessel elasticity – preventing inflammation and endothelial deterioration

Hesperidin has a documented venotonic effect, efficiently supporting circulation, especially in the lower limbs. It is frequently used in formulas to combat chronic venous insufficiency, heavy legs, edema or post-thrombotic syndrome. The association with citrus bioflavonoids intensifies the vascular protection effect and provides lasting systemic support.

• Intense antioxidant activity and cellular protection against oxidative stress

Oxidative stress is implicated in almost all chronic conditions, from cardiovascular and neurodegenerative diseases to premature skin aging and immune disorders. Citrus bioflavonoids have remarkable antioxidant capacity, acting as scavengers for free radicals and supporting oxidative balance at the cellular level.

Key components contribute to:

✅ Neutralizing reactive oxygen species (ROS) – preventing damage to proteins, lipids and DNA
✅ Regenerating endogenous antioxidants such as glutathione and vitamin C
✅ Reducing oxidative damage induced by exposure to pollution, UV, smoking or stress

Hesperidin potentiates these effects by supporting the activity of cellular antioxidant enzymes, such as superoxide dismutase (SOD) and catalase. This mechanism contributes significantly to reducing chronic inflammation, maintaining tissue integrity and supporting cellular regeneration.

• Improving immune system function

Citrus flavonoids act at the interface between the oxidative and immune systems, supporting a balanced immune response. By reducing oxidative stress and regulating the inflammatory environment, bioflavonoids can contribute to maintaining an efficient and controlled immune response.

Among the observed effects are:

✅ Stimulation of phagocytosis and NK (natural killer) cell activity
✅ Reduction of systemic inflammation through inhibition of proinflammatory mediators
✅ Potentiation of antiviral and antibacterial response

Hesperidin has been associated with increased organism resistance against respiratory infections, supporting mucosal barrier balance. By modulating cytokines and supporting immunoglobulin production, this compound plays an essential role in the body's natural defense.

• Support for liver health and detoxification

The liver is the main organ involved in detoxifying harmful substances from the body, and citrus bioflavonoids actively contribute to hepatocyte protection and supporting hepatic enzymatic functions.

They act through:

✅ Reducing lipid peroxidation at hepatic level
✅ Protecting liver cells against exogenous and endogenous toxins
✅ Stimulating bile secretion and facilitating elimination of toxic compounds

In combination with hesperidin, the hepatoprotective effect is amplified, and hepatic metabolism is efficiently supported, including in cases of exposure to alcohol, hepatotoxic medications or unbalanced dietary regimens.

• Inflammatory balance and reduction of chronic inflammation

Low-grade chronic inflammation is a key factor in accelerated cellular aging and the onset of chronic diseases. Bioflavonoids and hesperidin have demonstrated anti-inflammatory properties by modulating proinflammatory gene expression and reducing the activity of inflammatory enzymes such as COX-2 and LOX.

Through their action:

✅ Production of inflammatory prostaglandins and leukotrienes is reduced
✅ Activation of the NLRP3 inflammatory complex is inhibited
✅ Levels of TNF-α, IL-6 and other inflammatory markers are regulated

These effects contribute to reducing joint pain, protecting the cardiovascular system and preventing connective tissue degradation. For people with chronic inflammation, autoimmune diseases or persistent pain, this citrus complex can bring significant improvement.

• Skin and connective tissue health

Citrus bioflavonoids and hesperidin indirectly contribute to skin health by supporting microcirculation, protection against oxidative stress and stimulating collagen synthesis. Good blood circulation at dermal level means more oxygenated, better nourished skin with greater regenerative capacity.

Observed benefits include:

✅ Improving skin appearance – luminosity, elasticity and redness reduction
✅ Supporting tissue healing and regeneration
✅ Protection against UV-induced photoaging

By maintaining vascular integrity and reducing inflammation, this supplement becomes effective support for healthy skin and resilient connective tissue, including in conditions such as couperose, capillary fragility or mature skin.

• Support for eye and brain health

The eye and brain are organs extremely sensitive to oxidative stress and microcirculation disorders. Citrus flavonoids have demonstrated the ability to protect the retina and neuronal tissues, improving cerebral blood circulation and neuronal oxygenation.

This translates to:

✅ Reducing the risk of macular degeneration
✅ Supporting visual acuity and retinal health
✅ Improving concentration, memory and reaction time

Hesperidin can act synergistically with other neuroprotective compounds, supporting synaptic plasticity and nerve cell resistance to metabolic stress. This effect makes Citrus Bioflavonoids Plus a valuable supplement for supporting cognitive functions and preventing age-associated neurological decline.

Suggested Use

1 capsule 1-3 times daily or as directed by a health care practitioner.

Other ingredients

Gelatin capsule (gelatin, purified water), magnesium stearate (vegetable grade).

Contains no artificial colors, preservatives or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts or GMOs.

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Warnings

As with any supplement, consult your doctor before use if you are pregnant, nursing or trying to conceive, or if you are taking medications, have a medical condition or anticipate a surgery. Keep out of reach of children.

Sealed for your protection. Do not use if seal is broken. For freshness, keep in a cool, dry place.