No Flush Niacin 640 mg: Metabolic Energy, Lipid Profile Support, Circulation & Nervous-Cognitive Function – Advanced Formula with Inositol & Acetyl-L-Carnitine

No Flush Niacin, 640 mg, Life Extension is a complex dietary supplement designed to deliver the strategic benefits of niacin (vitamin B3) in a special, well-tolerated form, alongside two important cofactors for metabolism and cellular performance. The formula contains Niacin (from 800 mg inositol hexanicotinate) – 640 mg (4,000% NRV), Inositol (from 800 mg inositol hexanicotinate) – 160 mg, plus Acetyl-L-Carnitine Hydrochloride – 300 mg. This combination targets energy support, cardiovascular health, and neurological function, while providing a modern approach to maintaining metabolic balance.

Niacin is one of the key vitamins involved in converting food into energy because it is fundamental to the formation of the coenzymes NAD and NADP, indispensable in ATP production reactions, cellular repair processes, and in regulating carbohydrate and lipid metabolism. At the same time, niacin is known for its role in supporting circulation and cardiovascular health and has long been studied for its effects on lipid metabolism.

The major difference of this product is the “no flush” form: inositol hexanicotinate is a special form of niacin in which nicotinic acid molecules are bound to inositol. This structure is often associated with slower release, aiming to reduce the “flush” sensation (skin redness and warmth) that frequently occurs with some niacin forms. In this way, the product is intended for those who want concentrated niacin support but prefer improved tolerability and a more comfortable experience.

In addition, the presence of inositol complements the formula through its role in cellular signaling and nervous system balance, while acetyl-L-carnitine adds mitochondrial support, transporting fatty acids to the cell’s “energy powerhouses” and being appreciated for its impact on mental energy and cognitive function. Together, these ingredients create a multi-dimensional profile: energy, metabolism, circulation, vitality, and neurological support.

Detailed Benefits of No Flush Niacin (Niacin + Inositol + Acetyl-L-Carnitine)

• Supporting Cellular Energy and Metabolism via NAD/NADP

Cellular energy depends on the body’s ability to convert carbohydrates, fats, and proteins into ATP. Niacin is a direct precursor for NAD (nicotinamide adenine dinucleotide) and NADP, coenzymes involved in hundreds of metabolic reactions.

When metabolism is under pressure—through stress, intense activity, or a fast-paced lifestyle—adequate niacin intake can support energy production efficiency.
✅ Support for converting nutrients into energy (ATP)
✅ Support for essential redox reactions in mitochondria
✅ Support for daily vitality and metabolic resilience

This action makes niacin a central vitamin for people who want functional energy, not just temporary “stimulation.”

• Optimizing Lipid Metabolism and Supporting Cardiovascular Health

Niacin is one of the most studied vitamins in the context of lipid metabolism, because it influences how the body manages triglycerides and lipoproteins.

In a cardiovascular health approach, maintaining a balanced lipid profile is essential for protecting blood vessels and supporting efficient circulation.
✅ Support for metabolic processes involved in lipid balance
✅ Support for cardiovascular health through vitamin B3’s role
✅ Contribution to maintaining normal heart and vessel function

Through its mechanisms, niacin remains a nutrient of major interest for those seeking metabolic support with systemic impact.

• Circulation, Microcirculation, and Vascular Comfort – Without the Typical “Flush” Discomfort

Efficient circulation is vital for tissue oxygenation, nutrient delivery, and removal of metabolic byproducts. Niacin is known for its influence on peripheral circulation, but classic forms can cause redness and warmth (flush), sometimes unpleasant.

No Flush Niacin uses inositol hexanicotinate, a form that aims for gradual release and improved tolerability while keeping the focus on circulatory support.
✅ Support for blood flow and tissue oxygenation
✅ Support for microcirculation, important for skin and extremities
✅ Comfort-oriented form by reducing the flush sensation

As a result, the product may be easier to integrate into the daily routine for people sensitive to niacin.

• Nervous System Function and Neurocognitive Balance – The Role of Niacin and Inositol

The nervous system requires constant energy and efficient cellular signaling. Niacin contributes to normal nervous system function and to reducing fatigue, while inositol is involved in cellular communication processes and in supporting neurological balance.

Together, these two components can support mental resilience and the ability to adapt to stress.
✅ Support for normal nervous system function
✅ Support for mental clarity and emotional stability through efficient metabolism
✅ Inositol supports cellular signaling in nervous tissues

This profile makes the formula suitable for those who want support that reaches both metabolism and neurological function.

• Mitochondrial Support and “Clean” Energy with Acetyl-L-Carnitine

Acetyl-L-carnitine is a special form of carnitine recognized for supporting energy metabolism by transporting fatty acids into mitochondria, where they are converted into energy.

The “acetyl” component also makes it relevant for the nervous system and is associated with support for cognitive function and mental performance.
✅ Increasing efficiency of using fats as an energy source
✅ Support for vitality without harsh stimulants
✅ Support for mental energy and cognitive performance

In synergy with niacin (via NAD/NADP), acetyl-L-carnitine strengthens the “energy chain”: coenzyme availability + mitochondrial fuel.

• Carbohydrate Metabolism and Steady Energy Throughout the Day

Niacin contributes to normal macronutrient metabolism, including carbohydrates. When energy fluctuates (energy crashes, post-meal fatigue, intense daily rhythm), well-regulated metabolism can make a difference in maintaining consistency.

By supporting cellular energy pathways, the formula can contribute to more even energy output.
✅ Support for glucose metabolism and converting glucose into energy
✅ Help with maintaining more consistent vitality
✅ Support for metabolic resilience during demanding periods

This is an important advantage for active people who want stable performance, not temporary “peaks.”

• Support for Skin and Tissues Through Niacin’s Role in Cellular Renewal

Niacin is involved in cellular repair processes and maintaining tissue integrity, including skin.

Through its role in coenzyme synthesis and energy metabolism, vitamin B3 supports normal cell renewal and function, contributing to overall resilience.
✅ Maintaining skin health through metabolic support
✅ Supporting cellular renewal via NAD/NADP
✅ Contribution to optimal tissue function

This effect fits into the broader perspective of niacin: a vitamin with systemic impact, not just an “energizer.”

No Flush Niacin, 640 mg, Life Extension offers a complete approach to supporting metabolism and vitality: niacin in a well-tolerated form (inositol hexanicotinate), inositol for cellular signaling, and acetyl-L-carnitine for mitochondrial support and mental energy. The formula targets real energy, circulation, metabolic balance, and neurocognitive support, in a concentrated format suited for those seeking advanced benefits without the typical discomfort of classic niacin.

Directions for Use

Read the entire label and follow instructions carefully before use.
Take one (1) capsule with food, or as recommended by a physician.

Other Ingredients

gelatin, vegetable stearate.

Warnings