Discomfort Relief PEA600 (Inflammation, Neuropathic Pain) – Natural Analgesia, Neuro-immune Balance and Enhanced Mobility

Discomfort Relief PEA600 from Life Extension is a premium supplement formulated with Palmitoylethanolamide (PEA) 600 mg, an endogenous lipid amide naturally present in the body, recognized for its role in regulating inflammatory response and pain sensation. PEA belongs to the "ALIAmide" family – molecules involved in self-protective control of inflammation – and acts through multiple convergent pathways, including mast cell modulation, microglia regulation and PPAR-α receptor activation. By supporting these mechanisms, PEA contributes to reducing hypersensitivity, calming irritated tissues and restoring nervous comfort. The Life Extension formula delivers a concentrated dose of 600 mg per capsule, suitable for rapid support of daily comfort, joint mobility and quality of life in people with persistent discomfort or recurrent episodes of nervous and musculoskeletal irritation.

Detailed benefits of PEA (Palmitoylethanolamide) 600 mg

• Regulation of inflammatory response and calming of irritated tissues

Inflammation is a protective mechanism, but when it persists, it can fuel discomfort and stiffness. PEA acts as a "fine modulator" of inflammatory cascades, contributing to:
• Mast cell stabilization and reduction of irritative mediator release
• Reduction of hyperalgesia and peripheral sensitization
• Calming micro-inflammation in tissues subject to mechanical or chemical stress
By supporting inflammatory balance, PEA promotes a calmer tissue environment, helping to diminish sensations of burning, pressure or throbbing associated with prolonged discomfort.

• Comfort for neuropathic pain and nervous sensitivity

Neuropathic discomfort often involves nerve fiber sensitization and glial hyperactivity. PEA intervenes in neuro-immune circuits through:
✅ PPAR-α activation, with effects on gene expression involved in nociception
✅ Microglia and astrocyte modulation, reducing inflammatory "noise" at neuronal level
✅ Interactions with endocannabinoid-like system, supporting physiological pain control
The result is a gradual reduction in hypersensitivity, which can ease daily activities, walking, prolonged standing or desk work, where minor stimuli can become bothersome.

• Support for endocannabinoid-like system and neuronal homeostasis

PEA is not a classic cannabinoid, but functions synergistically with endogenous mechanisms involved in calming and neuronal balance. By influencing lipid mediators and key enzymes, PEA:
✅ Promotes maintenance of endogenous neuronal "calming" tone
✅ Reduces "overdrive" of sensory networks that perpetuate discomfort
✅ Helps restore homeostasis in over-stressed synapses
This fine, multimodal action explains PEA's good tolerability profile and usefulness in supporting long-term comfort.

• Joint mobility and musculoskeletal comfort

Stiffness on mobilization, palpation sensitivity or muscle tension can limit activity, sleep and performance. PEA 600 mg contributes to:
✅ Reducing signals that maintain sensation of "tension" in muscles and around joints
✅ Calming irritative points amplified by effort or poor posture
✅ Improving movement perception, for more fluid and less painful gestures
A body that moves freely responds better to exercise, stretching and daily routine, and perceived comfort during activities improves visibly.

• Functional neuroprotection and nerve signal quality

When nervous tissues are stressed, activated microglia can maintain a vicious circle of irritation. PEA:
• Supports microglia in a less reactive profile
• Reduces pro-inflammatory signals that distort nerve transmission
• Contributes to a more stable neural "background," easing adaptation to daily stimuli
This fine support can have echoes in hand, foot or area comfort with easily irritable nerves, where unpleasant sensations tend to persist.

• Recovery after effort and support for tissue resilience

After exercise, physical work or prolonged sitting periods, tissues can become "noisy" and reactive. PEA 600 mg helps with:
✅ Tempering post-effort discomfort without blocking positive adaptation
✅ Maintaining proportional inflammatory response, useful for recovery
✅ Supporting general comfort, for resuming activities with greater ease
Thus, active routine becomes more sustainable, and the body manages small daily challenges more efficiently.

• Sleep quality and daily comfort

Persistent discomfort can fragment sleep and affect daytime tone. By diminishing irritative stimuli, PEA can:
• Reduce awakenings related to muscular or nervous discomfort
• Improve perception of rest and nighttime recovery
• Support mental clarity and emotional balance during the day
Calmer sleep means a more productive day and better tolerance for demands.

• Emotional balance and well-being

Chronic discomfort influences mood. PEA, through modulation of neuro-immune networks and lipid signaling, supports:
✅ Reduction of irritative "background" that consumes mental resources
✅ Calmer perception of stimuli, with less reactivity
✅ General sense of well-being, with positive impact on social and professional interactions
By attenuating sensory noise, the mind can focus on tasks, and quality of life increases.

• Versatility and lifestyle integration

Whether the challenge comes from busy office periods, demanding manual projects, training or prolonged standing, PEA 600 mg:
✅ Adapts to daily needs, supporting smoother transition between demand and relaxation
✅ Helps maintain pleasure of movement, without fear of "exaggerated" tissue reactions
✅ Contributes to stable daily rhythm – less discomfort, more freedom of action
When the body is calmer, the mind is clearer, and activities return to normal with fewer interruptions.

• Key mechanisms working together

PEA's strength lies in its concerted action: PPAR-α for anti-inflammatory genetic regulation, mast cell stabilization for local mediator control, microglia modulation for reducing neural "echo," plus natural synergies with endogenous calming systems. This ensemble:
• Decreases intensity of irritative signals from periphery and at central level
• Helps restore proportionality of tissue responses
• Supports global resilience – body tolerates demands better, returning quickly to balance

Discomfort Relief PEA600 (Inflammation, Neuropathic Pain), Life Extension, with 600 mg Palmitoylethanolamide per capsule, represents a modern, physiological and well-tolerated option for those who want to transform daily comfort into a constant, not an exception. Through supporting neuro-immune balance and intelligent tissue calming, PEA600 restores mobility, relaxes movement and supports a sense of well-being that is felt, day after day.




 

Directions for Use

Chew 1 tablet once or twice daily or as recommended by a physician. Do not swallow tablets whole.




 

Other Ingredients

Maltodextrin, mannitol, microcrystalline cellulose, xylitol, red beet, vegetable stearate, berry flavor, citric acid, stearic acid, silica, stevia extract, starch.

Warnings