Indole-3-Carbinol (I3C) 200 mg: Estrogen Balance, Active Detox and Cellular Protection – Hormonal Metabolism and Liver Health

Indole-3-Carbinol (I3C) 200 mg, Now Foods is a specialized supplement designed to support estrogen metabolism balance, natural detoxification mechanisms and cellular protection against oxidative stress. The formula brings together I3C (200 mg) – an indolic compound naturally derived from cruciferous vegetables (broccoli, cabbage, cauliflower) – and flax seed lignan extract (200 mg), a valuable source of enterolignin precursors with role in fine modulation of hormonal responses. Through this association, the product aims to support balanced hormonal profile, hormone-sensitive tissue health and liver functions involved in biotransformation of endogenous and exogenous compounds.
 

I3C is recognized for its ability to support physiological pathways of estrogen metabolism, favoring the formation of metabolites considered more favorable (2-hydroxy type) in phase I detox and facilitating their subsequent conjugation in phase II. Flax seed lignans complete the picture through nutritional effects on microbiota (enterolignin production) and balanced interaction at specific receptor levels. Together, these mechanisms contribute to general comfort, metabolic clarity and cellular resilience against daily demands.

Detailed Benefits of Indole-3-Carbinol (I3C) 200 mg, Now Foods

• Estrogen metabolism balance

Maintaining a favorable ratio between different estrogen metabolites is essential for well-being.

✅ Supporting the 2-hydroxy pathway in phase I – direction considered more advantageous from a physiological standpoint.
✅ Support for phase II (conjugation) – favoring controlled elimination through glucuronidation, sulfonation, glutathione.
✅ Hormonal comfort in daily rhythm, for both women and men, in the context of a balanced lifestyle.

Through fine modulation of metabolic conversions, I3C contributes to a harmonized estrogen profile, without forcing abrupt or unsustainable pathways.

• Active detox and liver health

The liver is the command center for biotransformation of internal and external compounds in the body.

✅ Physiological enzymatic activation involved in detox phases, supporting metabolic clarity.
✅ Coherent elimination flow, with reduction of unwanted stagnations.
✅ Synergy with nutrition – when accompanied by adequate intake of proteins, fiber, water and dietary antioxidants.

I3C functions as a nutritional cofactor in the orchestra of liver enzymes, encouraging a constant and predictable processing rhythm.

• Cellular protection and antioxidant defense

Oxidative stress can disrupt cellular structures and intracellular signaling.

✅ Indirect antioxidant support, through influence on internal defense pathways.
✅ Supporting cellular integrity against free radicals generated by demanding environments.
✅ Pro-homeostasis environment at sensitive tissue level.

This protection helps cells maintain their functions, contributing to stable metabolic status.

• I3C + flax seed lignans synergy

Flax seed lignans, metabolized by intestinal microbiota into enterolignans, complement I3C actions:

✅ Receptor-dependent modulation, with balanced responses to hormonal stimuli.
✅ Positive interaction with intestinal flora, supporting beneficial conversions.
✅ Complementary nutritional profile, useful in metabolic balancing contexts.

This synergy offers a "double filter" – hepatic and intestinal – for finer physiological management of hormonal compounds.

• Comfort of hormone-sensitive tissues

Estrogen balance is associated with comfort state in various tissues:

✅ Supporting balance at hormone-dependent tissue level.
✅ Better perception of well-being in the body's natural cycles.
✅ Gentle approach, oriented on supporting internal pathways, not forcing them.

This nutritional support aligns with daily routine, without therapeutic promises, but with emphasis on body homeostasis.

• Microbiota, functional fibers and enterolignans

Lignan extract from flax seed hull works in tandem with intestinal flora:

✅ Transformation into enterolignans (enterodiol, enterolactone) – compounds associated with hormonal response modulation.
✅ Prebiotic context that may favor intestinal ecological balance.
✅ Systemic effects through gut-liver-metabolism axis.

A harmonious microbiota can amplify perceived benefits of the formula, in relation to diet and lifestyle.

• Metabolic clarity, consistent energy and tone

Efficient metabolism, without congestion, means better allocated resources:

✅ Sensation of "metabolic lightness", useful in busy periods.
✅ Sustained tone, when metabolism is not burdened with persistent residues.
✅ Integration with movement, sleep and hydration, for better daily performance.

By optimizing metabolic flows, the body manages energy and recovery more coherently.

• Nutritional sustainability and diet compatibility

I3C naturally comes from cruciferous vegetables, and lignans from flax seeds – two valuable food groups:

✅ Compatible with balanced diets (including cruciferous vegetables, seeds, fiber).
✅ Complementary with antioxidant intake (polyphenols from fruits/green tea, carotenoids from vegetables).
✅ Without excess, focused on quality and coherence of daily intake.

The formula can be viewed as a concentrated extension of healthy eating habits.

• Quality and ingredient traceability

Now Foods ensures strict selection and control standards:

✅ I3C 200 mg – clear dose, easy to track in daily routine.
✅ Flax seed lignan extract 200 mg – from hull, rich source of active precursors.
✅ Coherent formula for supporting liver and hormonal pathways.


 

Directions for use

Take 1 capsule 1-2 times daily with food.



 

Other ingredients

Hypromellose (cellulose capsule), rice bran, silicon dioxide and magnesium stearate (vegetable source).
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Warnings

Caution: For adults only. Consult physician if pregnant/nursing, taking medication or have a medical condition. This product may cause digestive upset in some sensitive individuals. If you experience any gastrointestinal discomfort after using this product, reduce the dose or discontinue use.
Keep out of reach of children.
Natural color variation may occur in this product.