Calcium D-Glucarate 250 mg – Hepatic Detoxification (Phase II), Estrogen Balance, Metabolic Cleansing and Skin Clarity

Calcium D-Glucarate 250 mg, Swanson, is a modern supplement designed to support hepatic detoxification through the glucuronidation pathway (phase II), promoting safe elimination of spent metabolites, xenobiotics and endogenous compounds that need to be excreted. Each serving provides Calcium D-Glucarate 250 mg alongside Calcium 30 mg (2% NRV), in a stable form that, in the body, generates D-glucaro-1,4-lactone – a key intermediate with a role in β-glucuronidase inhibition. Through this mechanism, the product supports maintenance of glucuronidated conjugates, preventing their premature deconjugation in the intestine and thus reducing recirculation of unwanted substances. The result: a more coherent metabolic cleansing flow, with positive impact on hormonal balance (especially estrogenic), skin clarity, digestive comfort and daily vitality.

Detailed Benefits of Calcium D-Glucarate 250 mg, Swanson

• Hepatic Detoxification (Phase II) Through Glucuronidation

Glucuronidation is one of the most important conjugation pathways in the body, used to make lipophilic compounds more soluble and easy to eliminate.

Calcium D-Glucarate:
✅ Promotes the formation and stability of conjugates glucuronidated
✅ Supports neutralization of reactive metabolites and xenobiotics
✅ Contributes to a more predictable excretion flow through bile and urine
By optimizing this "exit channel," the body maintains its metabolic cleanliness in the rhythm of modern life.

• β-Glucuronidase Inhibition and Conjugate Protection

The enzyme β-glucuronidase can deconjugate compounds prepared for elimination, facilitating their reabsorption. D-glucaro-1,4-lactone derived from Calcium D-Glucarate:
✅ Inhibits β-glucuronidase, protecting conjugates
✅ Reduces enterohepatic recirculation of unwanted substances
✅ Supports constant elimination, without "steps backward"
This fine mechanism confers efficiency to natural detoxification processes.

• Estrogen Balance and Hormonal Hygiene

Estrogen metabolites are physiologically glucuronidated to be eliminated. When this flow is coherent:
✅ A balanced estrogen profile is supported
✅ Intestinal reexposure to already neutralized metabolites is limited
✅ General hormonal hygiene is promoted
Calcium D-Glucarate acts as a metabolic "guardian", supporting healthy hormonal dynamics.

• Skin Clarity and Clean Appearance

Skin often reflects the body's metabolic burden. By improving elimination flow:
✅ Pressure on secondary excretory pathways is reduced
✅ Skin homeostasis and cutaneous comfort are supported
✅ A well-maintained appearance is promoted, from inside to outside
Coherent detoxification is visible in tone and luminosity.

• Digestive Comfort and Balanced Microbiome

Excessive deconjugation at the intestinal level can disrupt the microbial ecosystem. Protecting conjugates:
✅ Reduces substrate for unwanted transformations
✅ Supports a more favorable microbial profile
✅ Contributes to daily digestive comfort
Transit with clear biochemical "messages" means a calmer intestine.

• Liver Support During Demanding Periods

Stress, irregular diet and pollutant exposure increase demand on detoxification pathways. Calcium D-Glucarate:
✅ Offers a valve for balancing excretion flow
✅ Reduces reloading with already neutralized metabolites
✅ Helps hepatic resilience in modern rhythm
The liver works more efficiently, and you feel functional lightness.

• Metabolic Sustainability and Clean Energy

When substances "to be discarded" leave the body at a constant rate:
✅ Metabolic noise decreases
✅ Focus and tone can become more stable
✅ A feeling of clean energy is obtained, without artificial peaks
Efficient cleansing opens space for constructive processes.

• Synergy with Vitamin D, Fiber and Hydration

A "metabolic hygiene" protocol is based on simple synergies:
✅ Dietary fibers support binding and excretion of conjugates
✅ Proper hydration promotes renal flow
✅ Good nutritional status (e.g. vitamin D) harmonizes hepatic pathways
Calcium D-Glucarate integrates easily into these habits.

• Support for Bile Metabolism and Elimination Through Biliary Tract

Part of the conjugates leave through bile, then are excreted. Keeping them intact:
✅ Promotes coherent flow of biliary flux
✅ Reduces reabsorption of neutralized compounds
✅ Supports normal liver–bile–intestine dynamics
It is one-way circulation, not a carousel of reexposure.

• Clean Profile, Clear Dosage and Utilitarian Calcium

The formula offers two transparently declared components:
✅ Calcium D-Glucarate 250 mg – the functional core of the product
✅ Calcium 30 mg (2% NRV) – modest intake, friendly to daily routine
This simplicity means predictability and traceability.

• Comfort During Lifestyle Change Periods

New diets, travel, fluctuating schedule can change metabolic rhythm. Calcium D-Glucarate:
✅ Helps standardize excretion in variable contexts
✅ Supports body's adaptation to new routines
✅ Contributes to more consistent well-being
Ideal when you need stability in the midst of change.

• Collateral Protection: Skin, Tissues, General State

By reducing recirculation of unwanted compounds:
✅ Pressure on sensitive tissues decreases
✅ A framework is created for repair and maintenance
✅ A general state of clarity and comfort is consolidated
Effects are felt "silently," but constantly.

• Fit with Holistic Objectives: Clarity, Routine, Balance

Calcium D-Glucarate suits those who pursue:
✅ Metabolic clarity and order in elimination processes
✅ Simple routine, without complicated formulas
✅ Balance between work, diet and recovery
It is an elegant tool for daily metabolic hygiene.

Calcium D-Glucarate 250 mg, Swanson combines glucuronidation support (phase II), β-glucuronidase inhibition and conjugate protection for a coherent detoxification pathway. Through its impact on estrogen balance, skin clarity, digestive comfort and hepatic resilience, this formula with Calcium D-Glucarate 250 mg and Calcium 30 mg (2% NRV) becomes an essential pillar in a modern strategy of metabolic cleansing and daily vitality.




 

Directions for Use

As a dietary supplement, take one capsule once to twice daily with 250 ml of water.




 

Other Ingredients

Gelatin, magnesium stearate, rice flour, microcrystalline cellulose (plant fiber).

Warnings

For adults only. Consult your healthcare provider before using this product or any other product if you are pregnant or nursing, taking medication or have a medical condition.
Keep out of reach of children. Do not use if seal is broken. Store in a cool, dry place.