Optimized Folate (L-Methylfolate) 1700 mcg: Optimal Methylation, Cardiovascular Health and Nervous System Support – Advanced Supplement with Active Folate

Optimized Folate (L-Methylfolate) 1700 mcg, Life Extension is a premium dietary supplement that provides one of the most advanced and bioavailable forms of folate: (6S)-5-methyltetrahydrofolate, calcium salt – known as L-methylfolate. Each tablet contains 1,700 mcg of active folate, covering 425% of the nutritional reference value, to support essential processes such as DNA synthesis, cell division, normal blood cell formation, homocysteine metabolism and proper nervous system function.

Folate is the natural form of vitamin B9, essential for the body, but not all forms are used equally efficiently. Unlike synthetic folic acid, L-methylfolate is the already active form, directly usable by the body, without requiring complex enzymatic conversions. This is important especially for people whose activity of certain enzymes (such as MTHFR) is reduced, which can limit the transformation of folic acid into its biologically active form.

By providing folate in its active methylated form, Optimized Folate (L-Methylfolate) supports methylation – an essential process for regulating gene expression, detoxification, neurotransmitter synthesis and optimal nervous system and cardiovascular function.

Detailed benefits of Optimized Folate (L-Methylfolate) 1700 mcg, Life Extension

• Supporting nervous system health and mood

Active folate plays a central role in the synthesis of neurotransmitters important for emotional balance, such as serotonin, dopamine and noradrenaline. Methylfolate participates in the methylation cycle, providing methyl groups necessary for the conversion of homocysteine into methionine, precursor of S-adenosylmethionine (SAMe), a molecule involved in mood regulation.

Through the generous intake of active folate, Optimized Folate (L-Methylfolate) can:
✅ support normal nervous system function
✅ support normal synthesis of neurotransmitters involved in well-being
✅ contribute to maintaining mental clarity and emotional balance.

This support for the nervous system makes L-methylfolate an important ally for people who want to support their cognitive functions and general well-being.

• Contribution to DNA synthesis and cell division

Folate is essential for the synthesis of genetic material (DNA and RNA) and for normal cell division. Growth, regeneration and tissue repair processes depend on adequate folate intake, especially in tissues with high cell renewal rate (bone marrow, mucous membranes, skin).

Optimized Folate (L-Methylfolate) 1700 mcg can:
✅ support proper DNA and RNA synthesis
✅ contribute to normal cell division
✅ support regeneration and recovery processes at the tissue level.

Through its structural and functional role, active folate is important for maintaining cellular integrity and for optimal functioning of the body as a whole.

• Supporting homocysteine metabolism and cardiovascular health

Homocysteine is an intermediate amino acid in methionine metabolism. Its levels must be maintained within normal limits, and folate has a key role in converting homocysteine into methionine.

Optimized Folate (L-Methylfolate), through its active form, can:
✅ contribute to normal homocysteine metabolism
✅ support maintaining blood vessel health
✅ support proper cardiovascular system function.

Direct provision of L-methylfolate helps the body efficiently use this nutrient in methylation reactions, important for metabolic balance and long-term cardiovascular protection.

• Normal blood formation and supporting tissue oxygenation

Folate is indispensable for normal red blood cell formation. Insufficient intake can affect erythrocyte production and efficient oxygen transport to tissues.

Through its content of 1,700 mcg active folate, Optimized Folate (L-Methylfolate) can:
✅ contribute to normal red blood cell formation
✅ support optimal oxygen transport to organs and muscles
✅ participate in maintaining an adequate level of energy and vitality.

This hematological support is essential for people who want to maintain their general tone and support normal circulatory system function.

• Supporting energy metabolism and reducing fatigue

Folate activates multiple nutrient transformation reactions into energy, being involved in amino acid metabolism and cellular processes that ensure ATP production.

Optimized Folate (L-Methylfolate) 1700 mcg can:
✅ contribute to normal energy metabolism
✅ help reduce the feeling of fatigue and exhaustion
✅ support the body in periods of increased physical and mental demand.

Through its role in DNA synthesis, blood cell production and methylation processes, active folate also indirectly supports the efficiency of energy systems at the cellular level.

• Support for periods with increased folate requirement

There are stages in life or contexts where the need for folate may be increased, for example in growth periods, accelerated regeneration or when the diet is less rich in natural folate sources (green vegetables, legumes, fortified cereals).

Through its high dose and active form, Optimized Folate (L-Methylfolate) can:
✅ ensure a concentrated intake of easily usable folate
✅ support growth and regeneration processes
✅ compensate for periods when the diet does not provide sufficient folate.

The methylated form is particularly useful for people who want a folate supplement "ready to use", without depending on the efficiency of folic acid conversion at the enzymatic level.

• Advantages of L-Methylfolate form versus regular folic acid

A defining element of this product is the use of the (6S)-5-methyltetrahydrofolate, calcium salt form – L-methylfolate – the same form that the body actually uses in biological reactions.

Compared to synthetic folic acid, L-methylfolate:
✅ is already in the active form, ready to be used by the body
✅ does not depend to the same extent on MTHFR enzyme activity for conversion
✅ can offer more efficient absorption and use at the cellular level, especially in people with reduced capacity to transform folic acid.

Optimized Folate (L-Methylfolate) 1700 mcg, Life Extension thus combines advanced nutritional science with a superior form of vitamin B9, oriented towards supporting methylation, cardiovascular health, the nervous system and fundamental processes of cell division and blood formation. It is a suitable choice for those seeking an active, efficient folate that is easy to integrate into the daily general health support routine.

Directions for use

Read the entire label and follow instructions carefully.
Take one (1) tablet daily with food or as recommended by a healthcare practitioner.


 

1700 mcg Version

8500 mcg Version

Other Ingredients

Microcrystalline cellulose, dicalcium phosphate, croscarmellose sodium, silica, vegetable stearate, stearic acid.

Warnings

Consult your healthcare provider if you are at risk for vitamin B12 deficiency, as high doses of folate may mask signs.
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is damaged.
Consult your physician if you are undergoing treatment for a medical condition or if you are pregnant or nursing.
Keep tightly closed in a cool, dry place.